1-Boc-4-甲烷磺酰氧基哌啶合成路线 （共 48 条）
反应条件
1: sodium hydride / N,N-dimethyl-formamide / 12 h / 50 °C 2: hydrogenchloride / 1.5 h / 20 °C View Scheme
参考文献
ABBOTT LABORATORIES; ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD.; WANG, Xueqing; MEYER, Michael; YAO, Betty; GUO, Tao; WEI, Guo Ping,Robert; WANG, Lijuan, Jane
Patent: WO2013/10453 A1, 2013 ;
反应条件
1: caesium carbonate / N,N-dimethyl-formamide / 24 h / 70 °C 2: trifluoroacetic acid / dichloromethane / 6 h / 20 °C View Scheme
参考文献
PIERRE FABRE MEDICAMENT; Leroy, Isabelle; Dupont-Passelaigue, Elisabeth; Mialhe, Samuel; Junquero, Didier; Valeille, Karine
Patent: US2013/40928 A1, 2013 ;
反应条件
caesium carbonate in N,N-dimethyl-formamide T=65°C; 7 h;
参考文献
Forest Laboratories Holdings Limited
Patent: US2009/239810 A1, 2009 ;
Location in patent: Page/Page column 22-23 ;
US 20090239810 A1
反应条件
1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 16 h / 80 °C 2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 14 h / 0 - 20 °C 3: trimethylsilyl iodide / N,N-dimethyl-formamide / 20 °C / |Cooling with ice 4: pyridinium p-toluenesulfonate / dichloromethane / 20 °C 5: 1,8-diazabicyclo[5.4.0]undec-7-ene / 27 h / 80 °C 6: hydrogenchloride / dichloromethane; ethyl acetate; methanol / 0 - 20 °C 7: Dess-Martin periodane / dichloromethane / 2 h / 20 °C View Scheme
参考文献
XI, Ning; WANG, Tingjin; YI, Lei
Patent: WO2013/138210 A1, 2013 ;
反应条件
sodium hydride in DMF (N,N-dimethyl-formamide) T=60°C; 16 h;
参考文献
Schering Corporation
Patent: US2004/122018 A1, 2004 ;
Location in patent: Page 32 ;
反应条件
NaH in N,N-dimethyl-formamide
参考文献
Schering Corporation
Patent: US6362188 B1, 2002 ;
US 6362188 B1
反应条件
sodium iodide; triethanolamine in dichloromethane; acetone
参考文献
Merck and Co., Inc.
Patent: US6265434 B1, 2001 ;
US 6265434 B1
反应条件
potassium carbonate; tetrabutyl-ammonium chloride in water T=20 - 101°C; Heating / reflux;
参考文献
OTSUKA PHARMACEUTICAL CO., LTD.
Patent: WO2005/92832 A1, 2005 ;
Location in patent: Page/Page column 44-46 ;
反应条件
1: triethylamine / N,N-dimethyl-formamide / 100 °C 2: methanol; sodium methylate / 5 h / 0 - 20 °C View Scheme
参考文献
MERCK SHARP and DOHME CORP.; WALSH, Shawn; PASTERNAK, Alexander; CATO, Brian; FINKE, Paul, E.; FRIE, Jessica; FU, Qinghong; KIM, Dooseop; PIO, Barbara; SHAHRIPOUR, Aurash; SHI, Zhi-Cai; TANG, Haifeng
Patent: WO2013/39802 A1, 2013 ;
反应条件
1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 16 h / 80 °C 2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 14 h / 0 - 20 °C View Scheme
参考文献
XI, Ning; WANG, Tingjin; YI, Lei
Patent: WO2013/138210 A1, 2013 ;
