5-异丙基-4-硝基-1H-吡唑-3-羧酸合成路线 （共 4 条）
反应条件
sulfuric acid; nitric acid 1.) room temp., 1 h 2.) 100 deg C, 6 h;
参考文献
Baraldi; Cacciari; Leoni; Recanatini; Roberti; Rossi; Manfredini; Periotto; Simoni
Farmaco, 1991 , vol. 46, # 11 p. 1337 - 1350
反应条件
1: MeONa / methanol / 24 h / Ambient temperature 2: 70 percent / hydrazine hydrate, acetic acid / 8 h / Heating 3: 82 percent / fuming nitric acid, fuming sulfuric acid / 1.) room temp., 1 h 2.) 100 deg C, 6 h View Scheme
参考文献
Baraldi; Cacciari; Leoni; Recanatini; Roberti; Rossi; Manfredini; Periotto; Simoni
Farmaco, 1991 , vol. 46, # 11 p. 1337 - 1350
反应条件
1: SOCl2 / 2 h / Heating
2: NH3 / acetone; H2O / -5 °C
3: 96 percent / H2 / Raney nickel / methanol; H2O / 9 h / 20 °C / atmospheric pressure
4: 78.5 percent / 0.5 h / 180 °C
View Scheme
参考文献
Krystof, Vladimir; Moravcova, Daniela; Paprskarova, Martina; Barbier, Pascale; Peyrot, Vincent; Hlobilkova, Alice; Havlicek, Libor; Strnad, Miroslav
European Journal of Medicinal Chemistry, 2006 , vol. 41, # 12 p. 1405 - 1411
反应条件
1: SOCl2 / 2 h / Heating
2: NH3 / acetone; H2O / -5 °C
3: 96 percent / H2 / Raney nickel / methanol; H2O / 9 h / 20 °C / atmospheric pressure
View Scheme
参考文献
Krystof, Vladimir; Moravcova, Daniela; Paprskarova, Martina; Barbier, Pascale; Peyrot, Vincent; Hlobilkova, Alice; Havlicek, Libor; Strnad, Miroslav
European Journal of Medicinal Chemistry, 2006 , vol. 41, # 12 p. 1405 - 1411
