1: 1.) thallium(III) nitrate (TTN), 2.) NaHSO3 / 1.) MeOH, 60 deg C, 2.) 0 deg C, 30 min 2: 1.) H2, 2.) 10percent HCl / 10percent Pd/C / 1.) MeOH, 2.) MeOH, reflux 3: aq. NaBH4 / tetrahydrofuran / 0.5 h / 0 °C 4: TsOH*H2O / toluene / 110 °C 5: BCl3 / CH2Cl2 / 1 h / -70 - -65 °C View Scheme

<b>Multi-step reaction with 2 steps<br /> </b>1: KOH / ethanol / Heating<br />2: K₂CO₃ / dimethylformamide / 120 &deg;C<br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '4267587', constants.ctx, '0')">potassium carbonate</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '605365', constants.ctx, '0')">N,N-dimethyl-formamide</a> <br />T=120&deg;C;&nbsp;<br /> &nbsp;