N-[(2'-氰基[1,1'-联苯]-4-基)甲基]-1-[(1-氧代戊基)氨基]环戊烷甲酰胺合成路线 （共 8 条）
反应条件
benzotriazol-1-ol; dicyclohexyl-carbodiimide in dichloromethane T=25 - 35°C;
参考文献
Satyanarayana, Bollikonda; Sumalatha, Yasareni; Sridhar, Chaganti; Venkatraman, Sundaram; Reddy, Padi Pratap
Heterocyclic Communications, 2006 , vol. 12, # 5 p. 323 - 328
反应条件
1: With potassium iodide; potassium hydroxide in acetonitrile T=20°C; 2 h; 2: With hydrogenchloride in water; acetonitrile pH=4 - 5; Product distribution / selectivity;
参考文献
KRKA, tovarna zdravil, d.d., Novo mesto
Patent: EP2194050 A1, 2010 ;
Location in patent: Page/Page column 12 ;
反应条件
benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide in dichloromethane T=38 - 41°C; 7 h;
参考文献
Rao, Korrapati V. V. Prasada; Dandala, Ramesh; Handa, Vijay K.; Rao, Inti V. Subramanyeswara; Rani, Ananta; Naidu, Andra
Synthetic Communications, 2007 , vol. 37, # 17 p. 2897 - 2905
反应条件
1: triethylamine / CH2Cl2 / 2.67 h / 0 - 5 °C 2: 654 g / aq. hydrochloric acid / 2 h / 55 - 60 °C 3: 93 percent / dicyclohexylcarbodiimide; 1-hydroxybenzotriazole; diisopropylethylamine / CH2Cl2 / 7 h / 38 - 41 °C View Scheme
参考文献
Satyanarayana, Bollikonda; Sumalatha, Yasareni; Sridhar, Chaganti; Venkatraman, Sundaram; Reddy, Padi Pratap
Heterocyclic Communications, 2006 , vol. 12, # 5 p. 323 - 328
反应条件
1: 654 g / aq. hydrochloric acid / 2 h / 55 - 60 °C 2: 93 percent / dicyclohexylcarbodiimide; 1-hydroxybenzotriazole; diisopropylethylamine / CH2Cl2 / 7 h / 38 - 41 °C View Scheme
参考文献
Rao, Korrapati V. V. Prasada; Dandala, Ramesh; Handa, Vijay K.; Rao, Inti V. Subramanyeswara; Rani, Ananta; Naidu, Andra
Synthetic Communications, 2007 , vol. 37, # 17 p. 2897 - 2905
反应条件
1: 82 percent / sodium hydroxide / H2O; toluene / 2 h / 0 - 10 °C 2: 96 percent / 1-hydroxybenzotriazole; dicyclohexyl carbodiimide / CH2Cl2 / 25 - 35 °C View Scheme
参考文献
Satyanarayana, Bollikonda; Sumalatha, Yasareni; Sridhar, Chaganti; Venkatraman, Sundaram; Reddy, Padi Pratap
Heterocyclic Communications, 2006 , vol. 12, # 5 p. 323 - 328
反应条件
1: With sodium azide; tributyltin chloride; N,N-dimethyl-formamide in o-xylene T=15 - 155°C; 1 h; 2: With hydrogenchloride in dichloromethane; o-xylene; water T=20°C; 1 h; Product distribution / selectivity;
参考文献
AUROBINDO PHARMA LIMITED
Patent: WO2007/122508 A2, 2007 ;
Location in patent: Page/Page column 21 ;
反应条件
1: With toluene-4-sulfonic acid in toluene 18 h; Reflux; 2: With sodium hydroxide in water; toluene pH=6.59; Product distribution / selectivity;
参考文献
KRKA, tovarna zdravil, d.d., Novo mesto
Patent: EP2194050 A1, 2010 ;
Location in patent: Page/Page column 5; 9; 13 ;
