trifluoroacetic acid in dichloromethane 8 h;

1: 66 percent / K2CO3 / acetone / 12 h / Ambient temperature 2: 92 percent / NaH / tetrahydrofuran / 3 h / Ambient temperature 3: 85 percent / H2 / PtO2 / ethyl acetate / 5 h / Ambient temperature 4: 66 percent / NaH / dimethylformamide / 3 h / Ambient temperature 5: NaH / dimethylformamide / 3 h / Ambient temperature 6: satd. aq. Na2S2O4 7: 88 percent / K2CO3 / acetone / 6 h / 45 °C 8: 72 percent / CF3COOH / CH2Cl2 / 8 h View Scheme

1: 98 percent / satd. aq. Na2S2O4 / CHCl3 2: 66 percent / K2CO3 / acetone / 12 h / Ambient temperature 3: 92 percent / NaH / tetrahydrofuran / 3 h / Ambient temperature 4: 85 percent / H2 / PtO2 / ethyl acetate / 5 h / Ambient temperature 5: 66 percent / NaH / dimethylformamide / 3 h / Ambient temperature 6: NaH / dimethylformamide / 3 h / Ambient temperature 7: satd. aq. Na2S2O4 8: 88 percent / K2CO3 / acetone / 6 h / 45 °C 9: 72 percent / CF3COOH / CH2Cl2 / 8 h View Scheme

1: 92 percent / NaH / tetrahydrofuran / 3 h / Ambient temperature 2: 85 percent / H2 / PtO2 / ethyl acetate / 5 h / Ambient temperature 3: 66 percent / NaH / dimethylformamide / 3 h / Ambient temperature 4: NaH / dimethylformamide / 3 h / Ambient temperature 5: satd. aq. Na2S2O4 6: 88 percent / K2CO3 / acetone / 6 h / 45 °C 7: 72 percent / CF3COOH / CH2Cl2 / 8 h View Scheme

1: 85 percent / H2 / PtO2 / ethyl acetate / 5 h / Ambient temperature 2: 66 percent / NaH / dimethylformamide / 3 h / Ambient temperature 3: NaH / dimethylformamide / 3 h / Ambient temperature 4: satd. aq. Na2S2O4 5: 88 percent / K2CO3 / acetone / 6 h / 45 °C 6: 72 percent / CF3COOH / CH2Cl2 / 8 h View Scheme

1: 1.) NaNO2, conc. H2SO4, 2.) CuBr, 48percent aq.HBr / 1.) AcOH, 30 min, 2.) AcOH, 1 h 2: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, 110-120 deg C, 3 h 3: 94.5 percent / H2 / PtO2 / ethanol / 3 h 4: 1.) NaNO2, 40percent aq. H2SO4, 2.) H2O, Cu(NO3)2*3H2O, Cu2O / 1.) 0 - 5 deg C, 5 min, 2.) RT, 30 min View Scheme

1: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, 110-120 deg C, 3 h 2: 94.5 percent / H2 / PtO2 / ethanol / 3 h 3: 1.) NaNO2, 40percent aq. H2SO4, 2.) H2O, Cu(NO3)2*3H2O, Cu2O / 1.) 0 - 5 deg C, 5 min, 2.) RT, 30 min View Scheme

1: 94.5 percent / H2 / PtO2 / ethanol / 3 h 2: 1.) NaNO2, 40percent aq. H2SO4, 2.) H2O, Cu(NO3)2*3H2O, Cu2O / 1.) 0 - 5 deg C, 5 min, 2.) RT, 30 min View Scheme

1: 66 percent / NaH / dimethylformamide / 3 h / Ambient temperature 2: NaH / dimethylformamide / 3 h / Ambient temperature 3: satd. aq. Na2S2O4 4: 88 percent / K2CO3 / acetone / 6 h / 45 °C 5: 72 percent / CF3COOH / CH2Cl2 / 8 h View Scheme

1: NaH / dimethylformamide / 3 h / Ambient temperature 2: satd. aq. Na2S2O4 3: 88 percent / K2CO3 / acetone / 6 h / 45 °C 4: 72 percent / CF3COOH / CH2Cl2 / 8 h View Scheme