6-溴-1,2-二氢-2-氧代-4-吡啶乙酸甲酯合成路线 （共 7 条）
反应条件
1: KOH / ethanol / 48 h / 0 °C 2: PCl5 / CH2Cl2 / 9 h / 25 °C 3: 1.) HBr / 1.) CH2Cl2, a) -78 deg C, 1 h, b) RT, 8 h, 2.) CH2Cl2, RT, 2 h View Scheme
参考文献
Tetrahedron, , vol. 52, # 35 p. 11385 - 11404
反应条件
1: 70 percent 2: 95 percent / NaOH / ethanol 3: 1.) PCl5, 2.) HBr gas View Scheme
参考文献
Journal of the American Chemical Society, , vol. 114, # 14 p. 5863 - 5864
反应条件
phosphorus pentachloride; hydrogen bromide Yield given. Multistep reaction;
参考文献
Journal of the American Chemical Society, , vol. 114, # 14 p. 5863 - 5864
反应条件
1: PCl5 / CH2Cl2 / 9 h / 25 °C 2: 1.) HBr / 1.) CH2Cl2, a) -78 deg C, 1 h, b) RT, 8 h, 2.) CH2Cl2, RT, 2 h View Scheme
参考文献
Tetrahedron, , vol. 52, # 35 p. 11385 - 11404
反应条件
hydrogen bromide 1.) CH2Cl2, a) -78 deg C, 1 h, b) RT, 8 h, 2.) CH2Cl2, RT, 2 h; Yield given. Multistep reaction. Title compound not separated from byproducts;
参考文献
Tetrahedron, , vol. 52, # 35 p. 11385 - 11404
反应条件
sodium hydride; lithium bromide in ethylene glycol dimethyl ether
参考文献
Curran, Dennis P.; Liu, Hui
Journal of the American Chemical Society, 1992 , vol. 114, # 14 p. 5863 - 5864
反应条件
sodium hydride; lithium bromide in ethylene glycol dimethyl ether; N,N-dimethyl-formamide Yields of byproduct given;
参考文献
Hui, Liu; Sung-Bo, Ko; Josien, Hubert; Curran, Dennis P.
Tetrahedron Letters, 1995 , vol. 36, # 49 p. 8917 - 8920
