potassium carbonate in N,N-dimethyl-formamide T=60°C; 0.5 h;

1: 1) 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, 2) 1N NaOH / 1) dioxane, H2O, 2) dioxane, H2O, reflux 2: K2CO3 / dimethylformamide / 50 °C View Scheme

1: 1) 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, 2) 1N NaOH / 1) dioxane, H2O, 2) dioxane, H2O, reflux 2: K2CO3 / dimethylformamide / 50 °C View Scheme

1: 4 N aq. NaOH / methanol / 2 h / 60 °C 2: 78 percent / K2CO3 / dimethylformamide / 0.5 h / 60 °C View Scheme