乙基3-氨基-4,4,4-三氟-2-丁烯酸酯合成路线 （共 9 条）
反应条件
1: With sodium ethanolate 2: With ammonium acetate; acetic acid in cyclohexane 5 h; Heating / reflux;
参考文献
DEGUSSA AG
Patent: WO2004/16579 A1, 2004 ;
Location in patent: Page 9; 10 ;
参考文献
Lutz,A.W.; Trotto,S.H.
Journal of Heterocyclic Chemistry, 1972 , vol. 9, p. 513 - 522
反应条件
in dimethyl sulfoxide T=120°C; Substitution; 2 h;
参考文献
Park, Young Seok; Kim, Kyongtae
Tetrahedron Letters, 1999 , vol. 40, # 35 p. 6439 - 6442
反应条件
in dimethyl sulfoxide T=70°C; Substitution; 5 h;
参考文献
Tetrahedron Letters, , vol. 40, # 35 p. 6439 - 6442
反应条件
1: ethyl-3-amino-4,4,4-trifluoro-2-butenoate; acrolein 2: With sulfur Heating;
参考文献
Roy, Patrick J.; Dufresne, Claude; Lachance, Nicolas; Leclerc, Jean-Philippe; Boisvert, Michel; Wang, Zhaoyin; Leblanc, Yves
Synthesis, 2005 , # 16 art. no. M03305SS, p. 2751 - 2757
反应条件
in chlorobenzene 24 h; Heating;
参考文献
Liu, Chang-Ling; Li, Miao; Chi, Hui-Wei; Hou, Chun-Qing; Li, Zheng-Ming
Journal of Fluorine Chemistry, 2006 , vol. 127, # 6 p. 796 - 799
反应条件
trichlorophosphate in N-methyl-acetamide; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; chlorobenzene; Petroleum ether
参考文献
Monsanto Company
Patent: US4199506 A1, 1980 ;
参考文献
Gaede, Bruce J.; McDermott, Lisa L.
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 1 p. 49 - 54
反应条件
SCl2; triethylamine
1.) chlorobenzene, 100 deg C, 10 h, 2.) 30 min; Yield given. Multistep reaction;
参考文献
Lee, Len F.; Howe, Robert K.
Journal of Organic Chemistry, 1984 , vol. 49, # 25 p. 4780 - 4783
