2-氧代吲哚啉-6-甲酸甲酯合成路线 （共 6 条）
反应条件
hydrogen; acetic acid; palladium 10 on activated carbon T=20°C; P=2585.81 Torr; 2.5 h;
参考文献
Roth, Gerald J.; Heckel, Armin; Colbatzky, Florian; Handschuh, Sandra; Kley, Joerg; Lehmann-Lintz, Thorsten; Lotz, Ralf; Tontsch-Grunt, Ulrike; Walter, Rainer; Hilberg, Frank
Journal of Medicinal Chemistry, 2009 , vol. 52, # 14 p. 4466 - 4480
反应条件
hydrogen; acetic acid; palladium 10 on activated carbon T=115°C; P=2068.65 - 2585.81 Torr; 2 h;
参考文献
WO2009/71523 A1, ;
Page/Page column 6; 17-18 ;
参考文献
US2006/173183 A1, ;
Page/Page column 118-119 ;
反应条件
1: With methanol; sodium hydroxide; water 3 h; Heating / reflux; 2: With hydrogenchloride
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2006/64044 A1, 2006 ;
Location in patent: Page/Page column 21-22 ;
反应条件
1.1: toluene / 4 h / Reflux 2.1: acetic anhydride / toluene / Reflux 2.2: 120 h / 20 - 104 °C 3.1: potassium hydroxide; methanol / 0.67 h / Reflux 4.1: methanol / 8 h / Reflux View Scheme
参考文献
Roth, Gerald J.; Heckel, Armin; Colbatzky, Florian; Handschuh, Sandra; Kley, Joerg; Lehmann-Lintz, Thorsten; Lotz, Ralf; Tontsch-Grunt, Ulrike; Walter, Rainer; Hilberg, Frank
Journal of Medicinal Chemistry, 2009 , vol. 52, # 14 p. 4466 - 4480
