4-(三氟甲基)苯基氨基甲酸叔丁酯合成路线 （共 8 条）
反应条件
sodium hydroxide in tetrahydrofuran; water T=20°C; 36 h;
参考文献
WO2009/21696 A1, ;
Page/Page column 68 ;
WO 2009/021696 A1
反应条件
palladium diacetate; caesium carbonate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in 1,4-dioxane T=100°C; 2 h;
参考文献
Tetrahedron Letters, , vol. 51, # 33 p. 4445 - 4448
反应条件
in tetrahydrofuran 10 h; Heating / reflux;
参考文献
EP1908753 A1, ;
Page/Page column 106 ;
反应条件
1: 67 percent / s-BuLi / tetrahydrofuran / 2 h / -40 °C 2: 89 percent / 3N HCl / tetrahydrofuran / Heating View Scheme
参考文献
EGENIX, INC.; PATANE, Michael
Patent: WO2014/66304 A1, 2014 ;
反应条件
1: N-(tert-butoxycarbonyl)-4-(trifluoromethyl)aniline With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in hexanes; diethyl ether T=-78 - -10°C; 2.33333 h; 2: carbon dioxide in hexanes; diethyl ether T=-78°C; 1 h;
参考文献
LABORATORIOS ALMIRALL, S.A.
Patent: WO2009/21696 A1, 2009 ;
Location in patent: Page/Page column 68-69 ;
WO 2009/021696 A1
反应条件
hydrogenchloride in tetrahydrofuran
参考文献
Ono Pharmaceutical Co., Ltd.
Patent: US6448290 B1, 2002 ;
反应条件
1: N-(tert-butoxycarbonyl)-4-(trifluoromethyl)aniline With tert.-butyl lithium in tetrahydrofuran T=-40°C; 2: N,N-dimethyl-formamide in tetrahydrofuran
参考文献
Hewawasam, Piyasena; Chen, Nathan; Ding, Min; Natale, Joanne T.; Boissard, Christopher G.; Yeola, Sarita; Gribkoff, Valentin K.; Starrett, John; Dworetzky, Steven I.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 7 p. 1615 - 1618
反应条件
1.1: t-BuLi / tetrahydrofuran / -78 - -40 °C
1.2: tetrahydrofuran / -40 - 0 °C
2.1: 3 N HCl / ethanol / Heating
View Scheme
参考文献
Hewawasam, Piyasena; Fan, Wenhong; Knipe, Jay; Moon, Sandra L.; Boissard, Christopher G.; Gribkoff, Valentin K.; Starrett Jr., John E
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 13 p. 1779 - 1783
