R(-)-4-氰基-3-羟基丁酸乙酯合成路线 (共 24 条)
反应条件
sulfuric acid in ethanol
参考文献
Samsung Fine Chemicals Co., Ltd.
Patent: US6586616 B1, 2003 ;
反应条件
acetic acid in water T=105 - 110°C; 0.02125 h;
参考文献
PHOENIX CHEMICALS LIMITED
Patent: WO2003/97581 A1, 2003 ;
Location in patent: Page/Page column 12-13 ;
反应条件
in water T=25 - 35°C; pH=8 - 9.5; 7.33 h;
参考文献
SK ENERGY AND CHEMICAL INC.
Patent: WO2004/31131 A1, 2004 ;
Location in patent: Page 6-7 ;
反应条件
sulfuric acid T=80°C; 1 h;
参考文献
Bergeron, Sophie; Chaplin, David A.; Edwards, John H.; Ellis, Brian S. W.; Hill, Catherine L.; Holt-Tiffin, Karen; Knight, Jonathan R.; Mahoney, Thomas; Osborne, Andrew P.; Ruecroft, Graham
Organic Process Research and Development, 2006 , vol. 10, # 3 p. 661 - 665
反应条件
glucose dehydrogenase; ketoreductase in acetic acid n-butyl ester; water T=30 - 40°C; 16 h; Aqueous phosphate buffer; Product distribution / selectivity;
参考文献
CODEXIS, INC.
Patent: WO2005/18579 A2, 2005 ;
Location in patent: Page/Page column 60 ;
反应条件
sulfuric acid; sodium hydroxide in water T=40°C; pH=7.3; Enzymatic reaction;
参考文献
Ma, Steven K.; Gruber, John; Davis, Chris; Newman, Lisa; Gray, David; Wang, Alica; Grate, John; Huisman, Gjalt W.; Sheldon, Roger A.
Green Chemistry, 2010 , vol. 12, # 1 p. 81 - 86
反应条件
NaCN in ethanol; water
参考文献
Board of Trustees Operating Michigan State University
Patent: US6114566 A1, 2000 ;
反应条件
sulfuric acid T=0°C; 1 h; Heating / refluxNeat (no solvent);
参考文献
WO2003/106415 A2, ;
Page 21 ;
反应条件
D-glucose in phosphate buffer T=30°C; pH=7; 24 h;
参考文献
He, Chunmao; Chang, Dongliang; Zhang, Jie
Tetrahedron Asymmetry, 2008 , vol. 19, # 11 p. 1347 - 1351
反应条件
hydrogenchloride; calcium hydroxide powder; anhydrous sodium hydrogen carbonate; Calcium chloride; triethylamine in water; ethyl acetate