R(-)-4-氰基-3-羟基丁酸乙酯合成路线 （共 24 条）
反应条件
in ethanol; water T=45°C; 3 h;
参考文献
Occhiato, Ernesto G.; Scarpi, Dina; Guarna, Antonio
European Journal of Organic Chemistry, 2008 , # 3 p. 524 - 531
反应条件
1: hydrogen cyanide With halohydrin dehalogenase in water T=40°C; pH=7; 0.5 h; 2: (S)-4-chloro-3-hydroxybutyric acid ethyl ester in water pH=7; 21 h; Product distribution / selectivity;
参考文献
WO2005/18579 A2, ;
Page/Page column 54 ;
参考文献
Wang, Guijun; Hollingsworth, Rawle I.
Tetrahedron Asymmetry, 1999 , vol. 10, # 10 p. 1895 - 1901
反应条件
hydrogenchloride T=20°C; 0.5 h; Title compound not separated from byproducts.;
参考文献
Journal of the American Chemical Society, , vol. 124, # 31 p. 9024 - 9025
反应条件
1: nitrilase III; phosphate buffer / 22 h / 22 °C / pH 7 2: HCl / 0.5 h / 20 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 124, # 31 p. 9024 - 9025
反应条件
vector pACYCDuet-RB and vector pET30-halohydrin dehalogenase in Escherichia coli BL21 (DE3) in aq. buffer T=30°C; pH=7; 2 h; Enzymatic reaction; stereoselective reaction;
参考文献
Advanced Synthesis and Catalysis, , vol. 355, # 16 p. 3179 - 3190
反应条件
in water T=55°C; pH=8.5 - 9; 3 h; Product distribution / selectivity;
参考文献
WO2005/18579 A2, ;
Page/Page column 57-58 ;
反应条件
vector pCDFDuet-HF and vector pET30-(S)-alcohol dehydrogenase in Escherichia coli BL21(DE3) in aq. buffer T=30°C; pH=7; 10 h; Enzymatic reaction; stereoselective reaction;
参考文献
Advanced Synthesis and Catalysis, , vol. 355, # 16 p. 3179 - 3190
反应条件
sulfuric acid T=0°C;
参考文献
WO2003/106415 A2, ;
Figure 1 ;
参考文献
Advanced Synthesis and Catalysis, , vol. 355, # 9 p. 1808 - 1816
