N,N,N'-三甲基乙二胺合成路线 （共 26 条）
参考文献
Yakugaku Zasshi, , vol. 75, p. 159,162
Chem.Abstr., , p. 1779
反应条件
hydrogenchloride; n-butyllithium in tetrahydrofuran; hexane
参考文献
The Boots Company PLC
Patent: US5547972 A1, 1996 ;
反应条件
sodium hydroxide in chloroform; acetone
参考文献
E. I. Du Pont de Nemours and Company
Patent: US3944670 A1, 1976 ;
参考文献
Einhorn, J.; Luche, J. L.
Tetrahedron Letters, 1986 , vol. 27, # 16 p. 1791 - 1792
反应条件
in methanol T=35°C; 3 h;
参考文献
Pastor, Stephen D.; Togni, Antonio
Helvetica Chimica Acta, 1991 , vol. 74, # 5 p. 905 - 933
反应条件
n-butyllithium; chloro-trimethyl-silane in tetrahydrofuran; hexane
参考文献
Allergan, Inc.
Patent: US5082954 A1, 1992 ;
反应条件
1: N,N'-dicyclohexylcarbodiimide (DCC) / CH2Cl2 / 0.5 h / Ambient temperature 2: AlH3 / tetrahydrofuran / 0.08 h / Ambient temperature View Scheme
参考文献
De Costa; Radesca; Di Paolo; Bowen
Journal of Medicinal Chemistry, 1992 , vol. 35, # 1 p. 38 - 47
反应条件
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine in tetrahydrofuran T=20°C;
参考文献
Wyeth
Patent: US2010/3250 A1, 2010 ;
Location in patent: Page/Page column 27 ;
US 20100003250 A1
参考文献
van Heyningen,E.; Brown,C.N.
Journal of Medicinal Chemistry, 1965 , vol. 8, p. 174 - 181
反应条件
1: With n-butyllithium in tetrahydrofuran
Inert atmosphere;
2: With tert.-butyl lithium in tetrahydrofuran
Inert atmosphere;
参考文献
Ho, Chun-Yu
Chemical Communications, 2010 , vol. 46, # 3 p. 466 - 468
