S-(Z)-3,7,11-三甲基-1,6,10-十二烷三烯-3-醇合成路线 （共 10 条）
反应条件
zinc in diethyl ether; acetic acid 1 h; Ambient temperature;
参考文献
Kigoshi, Hideo; Ojika, Makoto; Shizuri, Yoshikazu; Niwa, Haruki; Yamada, Kiyoyuki
Tetrahedron Letters, 1982 , vol. 23, # 51 p. 5413 - 5414
反应条件
phosphatase; recombinant presilphiperfolan-8β-ol synthase; apyrase pH=7; aq. buffer;
参考文献
Wang, Chieh-Mei; Hopson, Russell; Lin, Xin; Cane, David E.
Journal of the American Chemical Society, 2009 , vol. 131, p. 8360 - 8361
反应条件
1: 84 percent / t-BuOOH, (-)-diethyl tartrate, Ti(i-PrO)4 / CH2Cl2 / 1 h / -50 - -45 °C 2: 96 percent / pyridine / 5 h / 0 °C 3: 100 percent / sodium iodide / acetone / 10 h / Ambient temperature 4: 97 percent / zinc / acetic acid; diethyl ether / 1 h / Ambient temperature View Scheme
参考文献
Kigoshi, Hideo; Ojika, Makoto; Shizuri, Yoshikazu; Niwa, Haruki; Yamada, Kiyoyuki
Tetrahedron Letters, 1982 , vol. 23, # 51 p. 5413 - 5414
反应条件
1: 100 percent / sodium iodide / acetone / 10 h / Ambient temperature 2: 97 percent / zinc / acetic acid; diethyl ether / 1 h / Ambient temperature View Scheme
参考文献
Kigoshi, Hideo; Ojika, Makoto; Shizuri, Yoshikazu; Niwa, Haruki; Yamada, Kiyoyuki
Tetrahedron Letters, 1982 , vol. 23, # 51 p. 5413 - 5414
反应条件
1: 96 percent / pyridine / 5 h / 0 °C 2: 100 percent / sodium iodide / acetone / 10 h / Ambient temperature 3: 97 percent / zinc / acetic acid; diethyl ether / 1 h / Ambient temperature View Scheme
参考文献
Kigoshi, Hideo; Ojika, Makoto; Shizuri, Yoshikazu; Niwa, Haruki; Yamada, Kiyoyuki
Tetrahedron Letters, 1982 , vol. 23, # 51 p. 5413 - 5414
反应条件
1: 97 percent / 2,6-lutidine / CH2Cl2 / 0.5 h / Ambient temperature 2: 1.) SeO2, 2.) NaBH4 / 1.) EtOH, reflux, 4 h 3: 48 percent / triphenylphosphine, CCl4 / 4 h / Heating 4: 1.) n-butyl lithium / 1.) a) -78 deg C, 0.5 h, b) 0.5 h, r.t. 2.) THF, -78 deg C, 0.5 h 5: 82 percent / (n-Bu)4NF / tetrahydrofuran / 18 h / Heating 6: 1.) n-BuLi, 2.) Li, EtNH2 / 1.) THF, 2.) -78 deg C, 20 min View Scheme
参考文献
Cane, David E.; Ha, Hyun-Joon; McIlwaine, Douglas B.; Pascoe, Keith O.
Tetrahedron Letters, 1990 , vol. 31, # 52 p. 7553 - 7554
反应条件
1: 1.) SeO2, 2.) NaBH4 / 1.) EtOH, reflux, 4 h 2: 48 percent / triphenylphosphine, CCl4 / 4 h / Heating 3: 1.) n-butyl lithium / 1.) a) -78 deg C, 0.5 h, b) 0.5 h, r.t. 2.) THF, -78 deg C, 0.5 h 4: 82 percent / (n-Bu)4NF / tetrahydrofuran / 18 h / Heating 5: 1.) n-BuLi, 2.) Li, EtNH2 / 1.) THF, 2.) -78 deg C, 20 min View Scheme
参考文献
Cane, David E.; Ha, Hyun-Joon; McIlwaine, Douglas B.; Pascoe, Keith O.
Tetrahedron Letters, 1990 , vol. 31, # 52 p. 7553 - 7554
反应条件
1: 48 percent / triphenylphosphine, CCl4 / 4 h / Heating 2: 1.) n-butyl lithium / 1.) a) -78 deg C, 0.5 h, b) 0.5 h, r.t. 2.) THF, -78 deg C, 0.5 h 3: 82 percent / (n-Bu)4NF / tetrahydrofuran / 18 h / Heating 4: 1.) n-BuLi, 2.) Li, EtNH2 / 1.) THF, 2.) -78 deg C, 20 min View Scheme
参考文献
Cane, David E.; Ha, Hyun-Joon; McIlwaine, Douglas B.; Pascoe, Keith O.
Tetrahedron Letters, 1990 , vol. 31, # 52 p. 7553 - 7554
反应条件
1: 1.) n-butyl lithium / 1.) a) -78 deg C, 0.5 h, b) 0.5 h, r.t. 2.) THF, -78 deg C, 0.5 h 2: 82 percent / (n-Bu)4NF / tetrahydrofuran / 18 h / Heating 3: 1.) n-BuLi, 2.) Li, EtNH2 / 1.) THF, 2.) -78 deg C, 20 min View Scheme
参考文献
Cane, David E.; Ha, Hyun-Joon; McIlwaine, Douglas B.; Pascoe, Keith O.
Tetrahedron Letters, 1990 , vol. 31, # 52 p. 7553 - 7554
反应条件
1: 82 percent / (n-Bu)4NF / tetrahydrofuran / 18 h / Heating 2: 1.) n-BuLi, 2.) Li, EtNH2 / 1.) THF, 2.) -78 deg C, 20 min View Scheme
参考文献
Cane, David E.; Ha, Hyun-Joon; McIlwaine, Douglas B.; Pascoe, Keith O.
Tetrahedron Letters, 1990 , vol. 31, # 52 p. 7553 - 7554
