1: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane T=20°C; 15 h; 2: With lithium hydroxide; water in tetrahydrofuran 1.5 h; 3: With hydrogenchloride in tetrahydrofuran; water pH=1;
参考文献
ZAPAQ, INC.; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS; OKLAHOMA MEDICAL RESEARCH FOUNDATION
Patent: WO2006/34277 A1, 2006 ;
Location in patent: Page/Page column 69-70 ;
WO 2006/034277 A1