4-溴-3-溴甲苯甲酸甲酯合成路线 （共 8 条）
反应条件
N-bromosuccinmide; dibenzoyl peroxide in dichloromethane; water 10 h; Heating / refluxIrradiation;
参考文献
GALDERMA RESEARCH and DEVELOPMENT
Patent: US2007/15931 A1, 2007 ;
Location in patent: Page/Page column 6 ;
反应条件
N-bromosuccinmide in tetrachloromethane
参考文献
Priestley, Eldon Scott; Decicco, Carl P.; Hudyma, Thomas W.; Zheng, Xiaofan
Patent: US2003/134853 A1, 2003 ;
反应条件
1: With N-bromosuccinmide in tetrachloromethane 2 h; Heating / reflux; 2: With 2,2'-azo-bisisobutyronitrile in tetrachloromethane Heating / reflux;
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2006/21418 A1, 2006 ;
Location in patent: Page/Page column 97 ;
WO 2006/021418 A1
反应条件
N-bromosuccinmide in chloroform T=70°C; 48 h; Inert atmosphere;
参考文献
MERCK SERONO S.A.; BOMBRUN, Agnes; QUATTROPANI, Anna; GONZALEZ, Jerome; DORBAIS, Jerome; KNIGHT, Chris; BAKER-GLENN, Charles
Patent: WO2012/4287 A1, 2012 ;
Location in patent: Page/Page column 66 ;
WO 2012/004287 A1
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in tetrachloromethane Reflux;
参考文献
Giorgi, Giorgio; Maiti, Swarupananda; Lopez-Alvarado, Pilar; Menendez, J. Carlos
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 8 p. 2722 - 2730
反应条件
1: 10.8 g / acetic acid / 12 h / 100 °C
2: 8.29 g / NaOH / methanol; H2O / 2 h / 20 °C
View Scheme
参考文献
Miura, Masanori; Seki, Norio; Koike, Takanori; Ishihara, Tsukasa; Niimi, Tatsuya; Hirayama, Fukushi; Shigenaga, Takeshi; Sakai-Moritani, Yumiko; Kawasaki, Tomihisa; Sakamoto, Shuichi; Okada, Minoru; Ohta, Mitsuaki; Tsukamoto, Shin-ichi
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 23 p. 7688 - 7705
反应条件
water in methanol
Alkaline conditions;
参考文献
Chang, Dong-Jo; Yoon, Eun-Young; Lee, Geon-Bong; Kim, Soon-Ok; Kim, Wan-Joo; Kim, Young-Myeong; Jung, Jong-Wha; An, Hongchan; Suh, Young-Ger
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 15 p. 4416 - 4420
反应条件
1: copper(l) iodide; tetra-(n-butyl)ammonium iodide; caesium carbonate / acetonitrile / 72 h / 65 °C / Inert atmosphere
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere
3: palladium diacetate; caesium carbonate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene / 1,4-dioxane / 19 h / 100 °C / Inert atmosphere
View Scheme
参考文献
Masters, Kye-Simeon; Wallesch, Manuela; Braese, Stefan
Journal of Organic Chemistry, 2011 , vol. 76, # 21 p. 9060 - 9067
