8-羟基[1,3]二氧代lo[4,5-g]喹啉-7-羧酸乙酯合成路线 (共 7 条)
反应条件
1: in methyloxirane T=120°C; 2 h; 2: With ammonium hydroxide in water pH=8;
参考文献
GENZYME CORPORATION; TEICHER, Beverly A.; SCHMID, Steven M.
Patent: WO2012/15875 A1, 2012 ;
Location in patent: Page/Page column 45 ;
反应条件
1: 71 percent / benzene / 3.5 h / Heating 2: PPE / 2 h / 120 °C View Scheme
参考文献
Acta Chimica Hungarica, , vol. 112, # 2 p. 241 - 252
反应条件
1: 71 percent / benzene / 3.5 h / Heating 2: PPE / 2 h / 120 °C View Scheme
参考文献
Acta Chimica Hungarica, , vol. 112, # 2 p. 241 - 252
反应条件
1.1: benzene / 3.5 h / Reflux 2.1: polyphosphate ester(PPE) / methyloxirane / 2 h / 120 °C 2.2: pH 8 View Scheme
反应条件
1: potassium hydroxide / ethanol / 20 h / Reflux 2: diphenylether / 1.5 h / Reflux View Scheme
参考文献
GENZYME CORPORATION; TEICHER, Beverly, A.; SCHMID, Steven, M.
Patent: WO2012/15901 A1, 2012 ;
参考文献
Pellerano; Savini; Massarelli; Bruni Fiaschi
Farmaco, 1990 , vol. 45, # 3 p. 269 - 284
反应条件
1: NaOH / ethanol; H2O / 48 h / Ambient temperature
2: 52 percent / various solvent(s) / 1.5 h / Heating
3: 63 percent / phosphoryl chloride / 5 h / Heating
View Scheme
参考文献
GENZYME CORPORATION; TEICHER, Beverly, A.; SCHMID, Steven, M.
Patent: WO2012/15901 A1, 2012 ;