1: 85 percent / tetramethylurea; AgOTf / CH2Cl2 / 12 h / 20 °C 2: 52 percent / copper(II) acetate; lithium acetate; palladium(II) acetate / dimethylformamide / 1 h / 100 °C 3: 86 percent / NaOMe / methanol; tetrahydrofuran / 1 h / 20 °C View Scheme

<b>Multi-step reaction with 2 steps<br /> </b>1: pyridine; 1,2-dichloro-ethane<br />2: 1,2-dichloro-ethane; hydrogen bromide; acetic acid<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: pyridine<br />2: hydrogen bromide; acetic acid / dichloromethane<br /> <br /> &nbsp;