2-(叔丁氧基羰基氨基)-2-(4-氟苯基)乙酸合成路线 （共 6 条）
反应条件
1: With sodium hydroxide in water; acetone T=20°C; 3 h; 2: With hydrogenchloride in water pH=1;
参考文献
CHIESI FARMACEUTICI S.p.A.
Patent: US2012/134934 A1, 2012 ;
Location in patent: Page/Page column 29 ;
反应条件
1: N-(tert-butoxycarbonyl)-α-(phenylsulfonyl)-4-fluorobenzylamine With TMS-SnBu3; cesium fluoride in N,N-dimethyl-formamide T=20°C; 0.0833333 h; Inert atmosphere; 2: carbon dioxide in N,N-dimethyl-formamide T=100°C; P=7500.75 Torr; 3 h; Autoclave; 3: With hydrogenchloride in diethyl ether; water; N,N-dimethyl-formamide pH=2; Inert atmosphere;
参考文献
Mita, Tsuyoshi; Chen, Jianyang; Sugawara, Masumi; Sato, Yoshihiro
Angewandte Chemie - International Edition, 2011 , vol. 50, # 6 p. 1393 - 1396
反应条件
1: With cesium fluoride in N,N-dimethyl-formamide T=100°C; P=7500.75 Torr; 3 h; Autoclave; 2: With hydrogenchloride in diethyl ether; water; N,N-dimethyl-formamide T=0°C; pH=2; Inert atmosphere;
参考文献
Mita, Tsuyoshi; Sugawara, Masumi; Hasegawa, Hiroyuki; Sato, Yoshihiro
Journal of Organic Chemistry, 2012 , vol. 77, # 5 p. 2159 - 2168
反应条件
1.1: formic acid / methanol; water / 60 h / 20 °C / Inert atmosphere 2.1: TMS-SnBu3; cesium fluoride / N,N-dimethyl-formamide / 0.08 h / 20 °C / Inert atmosphere 2.2: 3 h / 100 °C / 7500.75 Torr / Autoclave 2.3: pH 2 / Inert atmosphere View Scheme
参考文献
Mita, Tsuyoshi; Chen, Jianyang; Sugawara, Masumi; Sato, Yoshihiro
Angewandte Chemie - International Edition, 2011 , vol. 50, # 6 p. 1393 - 1396
反应条件
1.1: formic acid / methanol; water / 60 h / 20 °C / Inert atmosphere 2.1: TMS-SnBu3; cesium fluoride / N,N-dimethyl-formamide / 0.08 h / 20 °C / Inert atmosphere 2.2: 3 h / 100 °C / 7500.75 Torr / Autoclave 2.3: pH 2 / Inert atmosphere View Scheme
参考文献
Mita, Tsuyoshi; Chen, Jianyang; Sugawara, Masumi; Sato, Yoshihiro
Angewandte Chemie - International Edition, 2011 , vol. 50, # 6 p. 1393 - 1396
反应条件
dicyclohexyl-carbodiimide in dichloromethane T=20°C; 72 h;
参考文献
ASTRAZENECA AB
Patent: WO2005/111001 A1, 2005 ;
Location in patent: Page/Page column 85; 86 ;
WO 2005/111001 A1
