2-(Boc-氨基)-2-(3,4-二氯苯基)乙酸合成路线 （共 3 条）
反应条件
sodium hydroxide in tert-butyl alcohol 24 h; Ambient temperature;
参考文献
Shuman; Rothenberger; Campbell; Smith; Gifford-Moore; Gesellchen
Journal of Medicinal Chemistry, 1993 , vol. 36, # 3 p. 314 - 319
反应条件
1: 57 percent / H2, conc aq. HCl / 5percent Pd/C / ethanol / 6 h / 760 Torr / Ambient temperature 2: 48 percent / 2N aq. NaOH / 2-methyl-propan-2-ol / 24 h / Ambient temperature View Scheme
参考文献
Shuman; Rothenberger; Campbell; Smith; Gifford-Moore; Gesellchen
Journal of Medicinal Chemistry, 1993 , vol. 36, # 3 p. 314 - 319
反应条件
1: 98 percent / isobutyl nitrite, aq. KOH / methanol / 26 h / 50 - 90 °C 2: 57 percent / H2, conc aq. HCl / 5percent Pd/C / ethanol / 6 h / 760 Torr / Ambient temperature 3: 48 percent / 2N aq. NaOH / 2-methyl-propan-2-ol / 24 h / Ambient temperature View Scheme
参考文献
Shuman; Rothenberger; Campbell; Smith; Gifford-Moore; Gesellchen
Journal of Medicinal Chemistry, 1993 , vol. 36, # 3 p. 314 - 319
