1.1: water; sodium hydrogencarbonate; [Rh(NCMe)2(cod)][BF4] / tetrahydrofuran; methanol / 20 - 40 °C / |Inert atmosphere 2.1: DBBA; hydrogenchloride / tetrahydrofuran; water / 0.5 h / 60 - 65 °C / |Large scale 3.1: ammonia / water; ethanol / 2 h / 120 °C / |Autoclave; |Large scale 3.2: pH 6 / |Large scale View Scheme

1: water; sodium hydrogencarbonate; [Rh(NCMe)2(cod)][BF4] / tetrahydrofuran; methanol / 20 - 40 °C / |Inert atmosphere 2: DBBA; hydrogenchloride / tetrahydrofuran; water / 0.5 h / 60 - 65 °C / |Large scale 3: ammonia / isopropyl alcohol / 2.67 h / 80 - 89 °C View Scheme