N-(2-羟基-1r-甲基乙基)-十六酰胺合成路线 (共 2 条)
反应条件
1: hexadecanoic acid With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine in ethyl acetate T=20°C; 1 h; 2: (2R)-2-amino-1-propanol in ethyl acetate T=20°C; 12 h;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 19, # 4 p. 1520 - 1527
反应条件
T=120°C; 5 h; Inert atmosphere;
参考文献
WO2013/121449 A1, ;
Page/Page column 22-24 ;