1-羟基甲基环丙烷乙酸甲酯合成路线 （共 6 条）
反应条件
1: With sodium methylate in methanol 0.25 h; 2: With ammonium chloride in methanol T=20°C; 0.5 h;
参考文献
GILEAD SCIENCES, INC.; KOREAN RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
Patent: WO2009/5674 A2, 2009 ;
Location in patent: Page/Page column 403; 404 ;
反应条件
hydrogenchloride; potassium hydroxide in tetrahydrofuran; diethyl ether; ethanol
参考文献
Merck Frosst Canada, Inc.
Patent: US5270324 A1, 1993 ;
反应条件
1: 1-(hydroxymethyl)-cyclopropaneacetonitrile With potassium hydroxide; water in ethanol T=100°C; 18 h; 2: With hydrogenchloride in water; ethyl acetate T=0 - 10°C; pH=< 1; 0.25 h; 3: diazomethane in diethyl ether; ethyl acetate T=0°C; 0.166667 h;
参考文献
MERCK FROSST CANADA LTD.
Patent: WO2008/141462 A1, 2008 ;
Location in patent: Page/Page column 38 ;
WO 2008/141462 A1
反应条件
sulfuric acid T=20°C;
参考文献
Overeem, Arjanne; Gieling, Reinerus G.; Zhu, Jie; Thijs, Lambertus
Patent: US2005/245568 A1, 2005 ;
Location in patent: Page/Page column 9-10 ;
反应条件
sodium hydrogencarbonate; triethylamine in dichloromethane; N,N-dimethyl-formamide
参考文献
Merck Frosst Canada, Inc.
Patent: US5212180 A1, 1993 ;
US 5212180 A
反应条件
sodium hydrogencarbonate in dichloromethane; N,N-dimethyl-formamide
参考文献
Merck Frosst Canada, Inc.
Patent: US5428033 A1, 1995 ;
US 5428033 A
