(S)-N-BOC-4-氟苯基氨基乙酸合成路线 （共 6 条）
反应条件
1: With sodium carbonate in tetrahydrofuran; water T=20°C; 2: With hydrogenchloride pH=3;
参考文献
Bayer HealthCare AG
Patent: EP1187812 B1, 2005 ;
Location in patent: Page/Page column 27 ;
EP 1187812 B1
反应条件
N,N-dioctyl-1-octylamine; water in various solvent(s) T=37°C; pH=8.0; 20 h;
参考文献
Arosio, Dario; Caligiuri, Antonio; D'Arrigo, Paola; Pedrocchi-Fantoni, Giuseppe; Rossi, Cristina; Saraceno, Caterina; Servi, Stefano; Tessaro, Davide
Advanced Synthesis and Catalysis, 2007 , vol. 349, # 8-9 p. 1345 - 1348
反应条件
sec.-butyllithium; (-)-sparteine in hexane T=-78°C; 0.333333 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Tetrahedron Letters, , vol. 38, # 37 p. 6505 - 6508
反应条件
1.1: 80 percent / triethylamine / CH2Cl2 / 0 - 20 °C 2.1: (-)-sparteine; s-BuLi / toluene; cyclohexane / 3 h / -78 °C 2.2: toluene; cyclohexane / 0.33 h View Scheme
参考文献
Tetrahedron, , vol. 57, # 15 p. 2965 - 2972
反应条件
1.1: 80 percent / triethylamine / CH2Cl2 / 3 h 2.1: 80 percent / triethylamine / CH2Cl2 / 0 - 20 °C 3.1: (-)-sparteine; s-BuLi / toluene; cyclohexane / 3 h / -78 °C 3.2: toluene; cyclohexane / 0.33 h View Scheme
参考文献
Tetrahedron, , vol. 57, # 15 p. 2965 - 2972
反应条件
1.1: 80 percent / triethylamine / CH2Cl2 / 3 h 2.1: 80 percent / triethylamine / CH2Cl2 / 0 - 20 °C 3.1: (-)-sparteine; s-BuLi / toluene; cyclohexane / 3 h / -78 °C 3.2: toluene; cyclohexane / 0.33 h View Scheme
参考文献
Tetrahedron, , vol. 57, # 15 p. 2965 - 2972
