potassium hydroxide T=20°C; 3 h;

1: oxalyl chloride; DMF / CH2Cl2 / 12 h 2: Et3N; 4-N,N-dimethylaminopyridine / CH2Cl2 / 48 h / 0 - 20 °C View Scheme

1: α-phenylbenzeneacetic acid; 4-methyl-benzoic acid With thionyl chloride Combinatorial reaction / High throughput screening (HTS); 2: 2-(4-hydroxyphenyl)ethylamine; 1-adamantaneamine; 2-(4-methylphenyl)-ethylamine; 2-(3,4-dimethoxyphenyl)-ethylamine; phenethylamine; 2-(4-methoxy-phenyl)ethylamine; 3,4,5-trimethoxy-phenylamine; 2-(3-methoxy-phenyl)-ethylamine; 1-amino-2-(2-methoxyphenyl)ethane; (1R*,2S*)-2-methylamino-1-phenyl-1-propanol