1: Et3N / CH2Cl2 / 6 h / Ambient temperature 2: 89 percent / 1 M LiOH / ethanol / 2 h 3: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDCI) / dimethylformamide / 12 h / Ambient temperature 4: HCl(g) / 2 h / 0 - 20 °C 5: ammonia / ethanol / 8 h / Ambient temperature 6: H2 / 10percent Pd/C / methanol / 4 h / 2280 Torr / Ambient temperature 7: formic acid / 12 h / Ambient temperature View Scheme

1: H2 / 10percent Pd/C / ethyl acetate; methanol / Ambient temperature 2: Et3N / CH2Cl2 / 6 h / Ambient temperature 3: 89 percent / 1 M LiOH / ethanol / 2 h 4: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDCI) / dimethylformamide / 12 h / Ambient temperature 5: HCl(g) / 2 h / 0 - 20 °C 6: ammonia / ethanol / 8 h / Ambient temperature 7: H2 / 10percent Pd/C / methanol / 4 h / 2280 Torr / Ambient temperature 8: formic acid / 12 h / Ambient temperature View Scheme

1: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDCI) / dimethylformamide / 12 h / Ambient temperature 2: HCl(g) / 2 h / 0 - 20 °C 3: ammonia / ethanol / 8 h / Ambient temperature 4: H2 / 10percent Pd/C / methanol / 4 h / 2280 Torr / Ambient temperature 5: formic acid / 12 h / Ambient temperature View Scheme

1: H2 / 10percent Pd/C / methanol / Ambient temperature 2: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDCI) / dimethylformamide / 12 h / Ambient temperature 3: HCl(g) / 2 h / 0 - 20 °C 4: ammonia / ethanol / 8 h / Ambient temperature 5: H2 / 10percent Pd/C / methanol / 4 h / 2280 Torr / Ambient temperature 6: formic acid / 12 h / Ambient temperature View Scheme

1: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDCI) / dimethylformamide / 12 h / Ambient temperature 2: HCl(g) / 2 h / 0 - 20 °C 3: ammonia / ethanol / 8 h / Ambient temperature 4: H2 / 10percent Pd/C / methanol / 4 h / 2280 Torr / Ambient temperature 5: formic acid / 12 h / Ambient temperature View Scheme

1: 89 percent / 1 M LiOH / ethanol / 2 h 2: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDCI) / dimethylformamide / 12 h / Ambient temperature 3: HCl(g) / 2 h / 0 - 20 °C 4: ammonia / ethanol / 8 h / Ambient temperature 5: H2 / 10percent Pd/C / methanol / 4 h / 2280 Torr / Ambient temperature 6: formic acid / 12 h / Ambient temperature View Scheme

1: HCl(g) / 2 h / 0 - 20 °C 2: ammonia / ethanol / 8 h / Ambient temperature 3: H2 / 10percent Pd/C / methanol / 4 h / 2280 Torr / Ambient temperature 4: formic acid / 12 h / Ambient temperature View Scheme

1: H2 / 10percent Pd/C / methanol / 4 h / 2280 Torr / Ambient temperature 2: formic acid / 12 h / Ambient temperature View Scheme

in formic acid 12 h; Ambient temperature; Yield given;