4-(N-Boc-4-哌啶基)丁酸合成路线 （共 20 条）
反应条件
1: CH2Cl2 / Ambient temperature 2: 90 percent / H2 / 10percent Pd/C / ethyl acetate 3: 97 percent / NaOH / methanol View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 16 p. 2537 - 2551
反应条件
1: 99 percent / BH3 / tetrahydrofuran / 1 h 2: 1.) oxalyl chloride, DMSO, 2.) Et3N / 1.) CH2Cl2, -78 deg C, 20 min, 2.) CH2Cl2, from -78 deg C to RT, 1.5 h 3: CH2Cl2 / Ambient temperature 4: 90 percent / H2 / 10percent Pd/C / ethyl acetate 5: 97 percent / NaOH / methanol View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 16 p. 2537 - 2551
反应条件
1: 90 percent / H2 / 10percent Pd/C / ethyl acetate 2: 97 percent / NaOH / methanol View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 16 p. 2537 - 2551
反应条件
1: Et3N / H2O; dioxane / 96 h 2: 99 percent / BH3 / tetrahydrofuran / 1 h 3: 1.) oxalyl chloride, DMSO, 2.) Et3N / 1.) CH2Cl2, -78 deg C, 20 min, 2.) CH2Cl2, from -78 deg C to RT, 1.5 h 4: CH2Cl2 / Ambient temperature 5: 90 percent / H2 / 10percent Pd/C / ethyl acetate 6: 97 percent / NaOH / methanol View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 16 p. 2537 - 2551
反应条件
1: toluene / 95 - 105 °C 2: H2 / 10 percent Pd/C / ethanol 3: NaOH / tetrahydrofuran; H2O; methanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 13 p. 1629 - 1633
反应条件
1: H2 / 10 percent Pd/C / ethanol 2: NaOH / tetrahydrofuran; H2O; methanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 13 p. 1629 - 1633
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 6, # 21 p. 2601 - 2606
反应条件
sodium hydroxide in 1,4-dioxane; water T=0 - 20°C; pH=9; 3.25 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 19, # 7 p. 1960 - 1965
反应条件
1: 98 percent / BH3 / tetrahydrofuran / 1 h 2: 85 percent / Ph3P, CBr4 / tetrahydrofuran; acetonitrile / 24 h View Scheme
参考文献
Egbertson, Melissa S.; Chang, Charles T.-C.; Duggan, Mark E.; Gould, Robert J.; Halczenko, Wasyl; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 16 p. 2537 - 2551
反应条件
borane in tetrahydrofuran 1 h;
参考文献
Egbertson, Melissa S.; Chang, Charles T.-C.; Duggan, Mark E.; Gould, Robert J.; Halczenko, Wasyl; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 16 p. 2537 - 2551
