3-(甲烷磺酰氧基甲基)氮杂丁烷-1-羧酸叔丁酯合成路线 （共 3 条）
反应条件
diethylamine; 4-(N,N-dimethlyamino)pyridine in dichloromethane T=0 - 20°C; 16 h;
参考文献
PFIZER INC.
Patent: WO2006/21881 A2, 2006 ;
Location in patent: Page/Page column 61 ;
WO 2006/021881 A2
反应条件
1: methanesulfonic acid 1-benzhydryl-azetidine-3-ylmethyl ester With hydrogenchloride; hydrogen; palladium hydroxide on carbon in ethanol; water P=2068.65 Torr; 3 h; 2: di-tert-butyl dicarbonate With triethylamine in dichloromethane T=0 - 20°C; 2 h;
参考文献
Chambers, Mark Stuart; Curtis, Neil Roy; MacLeod, Angus Murray; Maxey, Robert James; Szekeres, Helen Jane
Patent: US2005/101586 A1, 2005 ;
Location in patent: Page/Page column 11 ;
反应条件
in tetrahydrofuran; methanol
T=70°C; 40 h;
参考文献
Eisai RandD Management Co., Ltd.
Patent: US2008/214815 A1, 2008 ;
Location in patent: Page/Page column 16 ;
