1,2,4-三甲氧基-5-硝基-苯合成路线 （共 40 条）
反应条件
hydrogen; palladium on activated charcoal in methanol T=20°C; P=775.722 Torr; 3 h;
参考文献
Downer, Nadale K.; Jackson, Yvette A.
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 20 p. 3039 - 3043
反应条件
1: methanol With sodium
2: 4-chloro-2,5-dimethoxy nitrobenzene in methanol
T=0°C; 48 h; Heating / reflux;
参考文献
Piotrowski, David W.; Rogers, Bruce N.; McWhorter JR., William W.; Walker, Daniel Patrick; Corbett, Jeffrey W.; Groppi JR., Vincent E.; Rudmann, Daniel G.
Patent: US2003/236287 A1, 2003 ;
Location in patent: Page 33, 34 ;
US 20030236287 A1
反应条件
potassium carbonate in DMF (N,N-dimethyl-formamide)
T=75 - 80°C; 20 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2004/46120 A2, 2004 ;
Location in patent: Page 168 ;
WO 2004/046120 A2
反应条件
nitrogen(IV) oxide in dichloromethane
in the dark; -78 deg C, 2 min; RT, 15 min;
参考文献
Rathore; Bosch; Kochi
Tetrahedron, 1994 , vol. 50, # 23 p. 6727 - 6758
反应条件
nitric acid
T=-5°C; 0.5 h;
参考文献
Downer, Nadale K.; Jackson, Yvette A.
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 20 p. 3039 - 3043
反应条件
nitric acid in acetic acid
T=10 - 15°C; 1 h;
参考文献
Cotelle, Philippe; Catteau, Jeanpierre
Synthetic Communications, 1996 , vol. 26, # 22 p. 4105 - 4112
反应条件
1: 1-bromo-4,5-dimethoxy-2-nitrobenzene With potassium phosphate; tri-tert-butyl phosphine; tris-(dibenzylideneacetone)dipalladium(0) in toluene
T=100°C; 20 h;
2: methyl iodide With potassium carbonate in water; N,N-dimethyl-formamide; toluene
T=100°C; 3 h; Further stages.;
参考文献
Chen, Guoshu; Chan, Albert S.C.; Kwong, Fuk Yee
Tetrahedron Letters, 2007 , vol. 48, # 3 p. 473 - 476
参考文献
Choay S.A.
Patent: US4714700 A1, 1987 ;
反应条件
1: concentrated sulfuric acid; fuming nitric acid
2: aqueous NaOH
View Scheme
参考文献
Dorn; Warren; Bullock
Journal of the American Chemical Society, 1939 , vol. 61, p. 144,146
参考文献
Dorn; Warren; Bullock
Journal of the American Chemical Society, 1939 , vol. 61, p. 144,146
