1: ethyl 1-methylpyridolt;3,4-bgt;indole-3-carboxylate With sodium hydride in N,N-dimethyl-formamide T=20°C; 0.0833333 h; 2: methyl iodide in N,N-dimethyl-formamide T=20°C; Heating / reflux; 3: With hydrogenchloride; sodium hydrogencarbonate more than 3 stages;

sodium hydride in N,N-dimethyl-formamide T=20°C; 1 h;

T=120°C; 36 h;

1: SOCl2 / 2 h / Heating 2: 75 percent / sulfur / xylene / 6 h / Heating 3: 82 percent / NaH / dimethylformamide / 1 h / 20 °C View Scheme

1: 80 percent / H2SO4 / H2O / 10 h / 20 °C 2: SOCl2 / 2 h / Heating 3: 75 percent / sulfur / xylene / 6 h / Heating 4: 82 percent / NaH / dimethylformamide / 1 h / 20 °C View Scheme