1: With tri-isopropoxy-borane in tetrahydrofuran; hexane T=-70 - -67.5°C; 1 h; 2: With hydrogenchloride in tetrahydrofuran; hexane; water T=-5°C; pH=~ 2; 1 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2008/144223 A2, 2008 ;
Location in patent: Page/Page column 9; 10 ;