1-(5-溴-1-苯并噻吩-3-基)乙酮合成路线 （共 4 条）
反应条件
tin(IV) chloride in 1,2-dichloro-ethane T=0 - 20°C; Friedel-Crafts acylation; 20 h;
参考文献
Mitsumori, Susumu; Tsuri, Tatsuo; Honma, Tsunetoshi; Hiramatsu, Yoshiharu; Okada, Toshihiko; Hashizume, Hiroshi; Inagaki, Masanao; Arimura, Akinori; Yasui, Kiyoshi; Asanuma, Fujio; Kishino, Junji; Ohtani, Mitsuaki
Journal of Medicinal Chemistry, 2003 , vol. 46, # 12 p. 2446 - 2455
反应条件
1: 42.35 g / PPA / chlorobenzene / 15 h / Heating 2: 90 percent / SnCl4 / 1,2-dichloro-ethane / 20 h / 0 - 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 12 p. 2446 - 2455
反应条件
1: NaOMe / methanol / 3.5 h / Heating 2: 42.35 g / PPA / chlorobenzene / 15 h / Heating 3: 90 percent / SnCl4 / 1,2-dichloro-ethane / 20 h / 0 - 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 12 p. 2446 - 2455
反应条件
sodium hydroxide; bromine in 1,4-dioxane T=0 - 20°C;
参考文献
Mitsumori, Susumu; Tsuri, Tatsuo; Honma, Tsunetoshi; Hiramatsu, Yoshiharu; Okada, Toshihiko; Hashizume, Hiroshi; Inagaki, Masanao; Arimura, Akinori; Yasui, Kiyoshi; Asanuma, Fujio; Kishino, Junji; Ohtani, Mitsuaki
Journal of Medicinal Chemistry, 2003 , vol. 46, # 12 p. 2446 - 2455
