(R)-(-)-N-苯甲基-2-苯基甘氨酸醇合成路线 （共 32 条）
反应条件
1: tetrahydrofuran / 2 h / -60 °C 2: concd. HCl / methanol / 1 h / Heating 3: toluene / 2 h / Heating 4: HIO4 / methanol / 1 h / 0 °C 5: NaBH4 / methanol / 1 h / Ambient temperature 6: CF3CO2H / CH2Cl2 / 1.5 h / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 30, # 34 p. 4539 - 4542
反应条件
1: diethyl ether / 0.25 h / 0 °C 2: tetrahydrofuran / 2 h / -60 °C 3: concd. HCl / methanol / 1 h / Heating 4: toluene / 2 h / Heating 5: HIO4 / methanol / 1 h / 0 °C 6: NaBH4 / methanol / 1 h / Ambient temperature 7: CF3CO2H / CH2Cl2 / 1.5 h / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 30, # 34 p. 4539 - 4542
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 24 h; Heating;
参考文献
Farmaco, Edizione Scientifica, , vol. 43, # 2 p. 181 - 187
反应条件
1.1: dichloromethane / 5 h / 20 °C 2.1: acetonitrile / 0.5 h / 20 °C 3.1: lithium trifluoromethane sulfonate / N,N-dimethyl-formamide / 0.5 h / 0 °C / Molecular sieve; Inert atmosphere 3.2: 0 °C / Inert atmosphere 3.3: 0 - 20 °C / Inert atmosphere 4.1: water; acetic acid / acetonitrile / 17 h / 80 °C 4.2: 17 h / 70 °C View Scheme
参考文献
Monbaliu, Jean-Christophe; Tinant, Bernard; Marchand-Brynaert, Jacqueline
Heterocycles, 2008 , vol. 75, # 10 p. 2459 - 2475
反应条件
hydrogen; palladium dichloride in methanol 1 h;
参考文献
Kaseda, Takehiko; Kikuchi, Toyohiko; Kibayashi, Chihiro
Tetrahedron Letters, 1989 , vol. 30, # 34 p. 4539 - 4542
反应条件
1: phenol / 3 h / Ambient temperature 2: 70percent H2SO4 / 15 h / 140 °C 3: H2 / 10percent Pd/C / 12 h / 760 Torr / Ambient temperature View Scheme
参考文献
Bettoni, Giancarlo; Franchini, Carlo; Perrone, Roberto; Tortorella, Vincenzo
Tetrahedron, 1980 , vol. 36, p. 409 - 415
反应条件
1: H2/PdCl2 / methanol / 1 h 2: toluene / 2 h / Heating View Scheme
参考文献
Kaseda, Takehiko; Kikuchi, Toyohiko; Kibayashi, Chihiro
Tetrahedron Letters, 1989 , vol. 30, # 34 p. 4539 - 4542
反应条件
1: H2/PdCl2 / methanol / 1 h 2: toluene / 2 h / Heating 3: DMAP / CH2Cl2 / 2 h / Ambient temperature 4: dimethylsulfoxide / 1 h / 90 °C 5: 2N NaOH / ethanol / 3 h / 90 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 30, # 34 p. 4539 - 4542
反应条件
1: H2/PdCl2 / methanol / 1 h 2: toluene / 2 h / Heating View Scheme
参考文献
Kaseda, Takehiko; Kikuchi, Toyohiko; Kibayashi, Chihiro
Tetrahedron Letters, 1989 , vol. 30, # 34 p. 4539 - 4542
反应条件
1.1: dichloromethane / 5 h / 20 °C 2.1: acetonitrile / 0.5 h / 20 °C 3.1: lithium trifluoromethane sulfonate / N,N-dimethyl-formamide / 0.5 h / 0 °C / Molecular sieve; Inert atmosphere 3.2: 0 °C / Inert atmosphere 3.3: 0 - 20 °C / Inert atmosphere 4.1: water; acetic acid / acetonitrile / 17 h / 80 °C View Scheme
参考文献
Monbaliu, Jean-Christophe; Tinant, Bernard; Marchand-Brynaert, Jacqueline
Heterocycles, 2008 , vol. 75, # 10 p. 2459 - 2475
