6-氯-1H-吲哚-5-甲腈合成路线 （共 4 条）
反应条件
potassium sec-butoxide in tetrahydrofuran T=75°C; 3 h;
参考文献
F. HOFFMANN-LA ROCHE AG; ALIAGAS-MARTIN, Ignacio; CRAWFORD, James; LEE, Wendy; MATHIEU, Simon; RUDOLPH, Joachim
Patent: WO2013/26914 A1, 2013 ;
Location in patent: Page/Page column 161 ;
WO 2013/026914 A1
反应条件
1: acetic acid; N-iodo-succinimide / 20 °C 2: tetrakis(triphenylphosphine) palladium(0); N-ethyl-N,N-diisopropylamine; copper(l) iodide / 70 °C / |Inert atmosphere 3: tetrabutyl ammonium fluoride / tetrahydrofuran / 75 °C 4: potassium sec-butoxide / tetrahydrofuran / 3 h / 75 °C View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; ALIAGAS-MARTIN, Ignacio; CRAWFORD, James; LEE, Wendy; MATHIEU, Simon; RUDOLPH, Joachim
Patent: WO2013/26914 A1, 2013 ;
WO 2013/026914 A1
反应条件
1: tetrakis(triphenylphosphine) palladium(0); N-ethyl-N,N-diisopropylamine; copper(l) iodide / 70 °C / |Inert atmosphere 2: tetrabutyl ammonium fluoride / tetrahydrofuran / 75 °C 3: potassium sec-butoxide / tetrahydrofuran / 3 h / 75 °C View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; ALIAGAS-MARTIN, Ignacio; CRAWFORD, James; LEE, Wendy; MATHIEU, Simon; RUDOLPH, Joachim
Patent: WO2013/26914 A1, 2013 ;
WO 2013/026914 A1
反应条件
1: tetrabutyl ammonium fluoride / tetrahydrofuran / 75 °C 2: potassium sec-butoxide / tetrahydrofuran / 3 h / 75 °C View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; ALIAGAS-MARTIN, Ignacio; CRAWFORD, James; LEE, Wendy; MATHIEU, Simon; RUDOLPH, Joachim
Patent: WO2013/26914 A1, 2013 ;
WO 2013/026914 A1
