2-甲酰基-5-硝基苯甲酸甲酯合成路线 （共 6 条）
反应条件
hydrogenchloride in 1,4-dioxane; water 5 h; Heating / reflux;
参考文献
Vertex Pharmaceuticals, Incorporated
Patent: US6344465 B1, 2002 ;
Location in patent: Page column 32 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide 4 h; Reflux;
参考文献
Mirabdolbaghi, Roya; Dudding, Travis
Tetrahedron, 2013 , vol. 69, # 15 p. 3287 - 3292
反应条件
1: 3-hydroxy-6-nitro-1-(3H)isobenzofuranone With 1,8-diazabicyclo[5.4.0]undec-7-ene in acetone 0.166667 h; 2: methyl iodide in acetone T=20°C; 4 h;
参考文献
Mal, Dipakranjan; Jana, Amit; Ray, Sutapa; Bhattacharya, Sourav; Patra, Asit; De, Saroj R.
Synthetic Communications, 2008 , vol. 38, # 22 p. 3937 - 3946
反应条件
1: N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile / 1,2-dichloro-ethane / 1 h / Reflux 2: water / 1 h / Reflux 3: potassium carbonate / N,N-dimethyl-formamide / 4 h / Reflux View Scheme
参考文献
Mirabdolbaghi, Roya; Dudding, Travis
Tetrahedron, 2013 , vol. 69, # 15 p. 3287 - 3292
反应条件
1: water / 1 h / Reflux 2: potassium carbonate / N,N-dimethyl-formamide / 4 h / Reflux View Scheme
参考文献
Mirabdolbaghi, Roya; Dudding, Travis
Organic Letters, 2012 , vol. 14, # 14 p. 3748 - 3751
参考文献
Wegscheider; Kusy v. Dubrav
Monatshefte fuer Chemie, 1903 , vol. 24, p. 828
