6-氟苯并[b]噻吩-2-羧酸合成路线 （共 4 条）
反应条件
1: With lithium hydroxide hydrate in tetrahydrofuran; methanol; water T=20°C; 6 h; 2: With hydrogenchloride in tetrahydrofuran; methanol; water pH=4;
参考文献
Cheng, Kui; Wang, Xiaohui; Yin, Hang
Journal of the American Chemical Society, 2011 , vol. 133, # 11 p. 3764 - 3767
反应条件
hydrogenchloride; iodine in nitrobenzene
参考文献
Ishihara Sangyo Kaisha Ltd.
Patent: US5304657 A1, 1994 ;
反应条件
1: potassium carbonate / dimethylformamide / 20 - 60 °C 2: KOH / ethanol; H2O / Heating View Scheme
参考文献
Cheng, Kui; Wang, Xiaohui; Yin, Hang
Journal of the American Chemical Society, 2011 , vol. 133, # 11 p. 3764 - 3767
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in N,N-dimethyl acetamide T=200°C; 1 h; microwave irradiation;
参考文献
Allen, Daniel; Callaghan, Owen; Cordier, Frederic L.; Dobson, David R.; Harris, John R.; Hotten, Terry M.; Owton, W. Martin; Rathmell, Richard E.; Wood, Virginia A.
Tetrahedron Letters, 2004 , vol. 45, # 52 p. 9645 - 9647
