丁氧羰基-L-7-羟基-1,2,3,4-四氢化异喹啉-3-羧酸合成路线 （共 6 条）
反应条件
palladium 10 on activated carbon; hydrogen; triethylamine in methanol
参考文献
Zhang, Yingjie; Fang, Hao; Feng, Jinhong; Jia, Yuping; Wang, Xuejian; Xu, Wenfang
Journal of Medicinal Chemistry, 2011 , vol. 54, # 15 p. 5532 - 5539
反应条件
sodium carbonate in 1,4-dioxane Acylation; 16 h;
参考文献
Page; McClory; Mischki; Schmidt; Butterworth; St-Onge; Labarre; Payza; Brown
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 2 p. 167 - 170
反应条件
1: With lithium hydroxide; water in tetrahydrofuran; methanol T=40°C; 4 h; 2: With hydrogenchloride in tetrahydrofuran; methanol; water T=0°C;
参考文献
EP1857444 A1, ;
Page/Page column 60 ;
反应条件
1: 55 percent / 35 percent HCl / 1,2-dimethoxy-ethane / 18.5 h / 72 °C 2: 78 percent / NaOH / dioxane; H2O / 5 h / 20 °C 3: 54 percent / Et3N; H2 / 10 percent Pd/C / methanol / 4 h / 75006 Torr View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 10, # 6 p. 1719 - 1729
反应条件
sodium hydrogencarbonate in tetrahydrofuran; water 12 h; Inert atmosphere;
参考文献
WO2013/192286 A1, ;
Paragraph 00163 ;
反应条件
1: 78 percent / NaOH / dioxane; H2O / 5 h / 20 °C 2: 54 percent / Et3N; H2 / 10 percent Pd/C / methanol / 4 h / 75006 Torr View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 10, # 6 p. 1719 - 1729
