(alphaR)-alpha-氨基-N-(4-硝基苯基)-苯丙酰胺合成路线 （共 9 条）
反应条件
methanol; acetyl chloride in dichloromethane T=20°C; 24 h;
参考文献
Gorske, Benjamin C.; Bastian, Brent L.; Geske, Grant D.; Blackwell, Helen E.
Journal of the American Chemical Society, 2007 , vol. 129, # 29 p. 8928 - 8929
反应条件
copper(l) iodide; potassium carbonate in toluene T=110°C; 24 h; Inert atmosphereSealed tube;
参考文献
Dong, Junyu; Wang, Yan; Xiang, Qinjie; Lv, Xirui; Weng, Wen; Zeng, Qingle
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 4 p. 692 - 696
反应条件
copper(l) iodide; potassium carbonate in toluene T=110°C; 24 h; Inert atmosphereSealed tube;
参考文献
Dong, Junyu; Wang, Yan; Xiang, Qinjie; Lv, Xirui; Weng, Wen; Zeng, Qingle
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 4 p. 692 - 696
反应条件
1.1: 1,1-carbonyldiimidazole / CH2Cl2 / 0.5 h / 20 °C 1.2: 1,8-diazabicyclo[5.4.0]undec-7-ene / CH2Cl2 / 20 h / 20 °C 2.1: acetyl chloride; methanol / CH2Cl2 / 24 h / 20 °C View Scheme
参考文献
Gorske, Benjamin C.; Bastian, Brent L.; Geske, Grant D.; Blackwell, Helen E.
Journal of the American Chemical Society, 2007 , vol. 129, # 29 p. 8928 - 8929
反应条件
1.1: 1,1-carbonyldiimidazole / CH2Cl2 / 0.5 h / 20 °C 1.2: 1,8-diazabicyclo[5.4.0]undec-7-ene / CH2Cl2 / 20 h / 20 °C 2.1: acetyl chloride; methanol / CH2Cl2 / 24 h / 20 °C View Scheme
参考文献
Okada; Tsuda; Teno; Nagamatsu; Okamoto; Nishi
Chemical and pharmaceutical bulletin, 1985 , vol. 33, # 12 p. 5301 - 5309
反应条件
hydrogen bromide; acetic acid
参考文献
Kawai, Yasushi; Matsuo, Takashi; Ohno, Atsuyoshi
Journal of the Chemical Society. Perkin Transactions 2, 2000 , # 4 p. 887 - 891
反应条件
2: 25percent HBr, acetic acid View Scheme
参考文献
Okada; Tsuda; Teno; Nagamatsu; Okamoto; Nishi
Chemical and pharmaceutical bulletin, 1985 , vol. 33, # 12 p. 5301 - 5309
反应条件
endopeptidase in various solvent(s) T=25°C; 1 h; pH=8.0; apparent rate of hydrolysis;
参考文献
Shimamori; Watanabe; Fujimoto
Chemical and pharmaceutical bulletin, 1986 , vol. 34, # 1 p. 275 - 280
反应条件
Streptomyces spp. 82F2 D-aminopeptidase in dimethyl sulfoxide T=20°C; pH=6.5; 0.0833333 h; aq. bufferEnzymatic reaction;
参考文献
Arima, Jiro; Ito, Hitomi; Hatanaka, Tadashi; Mori, Nobuhiro
Biochimie, 2011 , vol. 93, # 9 p. 1460 - 1469
