4-(4-羟基丁基)哌啶-1-甲酸叔丁酯合成路线 （共 16 条）
反应条件
1: 97 percent / NaOH / methanol 2: 98 percent / BH3 / tetrahydrofuran / 1 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 16 p. 2537 - 2551
反应条件
1.1: 92 percent / 1N NaOH / dioxane 2.1: 95 percent / (COCl)2; DMSO / CH2Cl2 / -78 °C 3.1: 40 percent / tetrahydrofuran 4.1: BH3*THF 4.2: 90 percent / H2O2; NaOH View Scheme
参考文献
Organic Letters, , vol. 4, # 4 p. 549 - 552
反应条件
1.1: 95 percent / (COCl)2; DMSO / CH2Cl2 / -78 °C 2.1: 40 percent / tetrahydrofuran 3.1: BH3*THF 3.2: 90 percent / H2O2; NaOH View Scheme
参考文献
Organic Letters, , vol. 4, # 4 p. 549 - 552
反应条件
1.1: 40 percent / tetrahydrofuran 2.1: BH3*THF 2.2: 90 percent / H2O2; NaOH View Scheme
参考文献
Organic Letters, , vol. 4, # 4 p. 549 - 552
反应条件
sodium hydroxide in tetrahydrofuran
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 6 p. 2028 - 2031
反应条件
carbon tetrabromide; triphenylphosphine in tetrahydrofuran; acetonitrile 24 h;
参考文献
Egbertson, Melissa S.; Chang, Charles T.-C.; Duggan, Mark E.; Gould, Robert J.; Halczenko, Wasyl; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 16 p. 2537 - 2551
