2-溴-5,6-二氯-1H-苯并咪唑合成路线 （共 3 条）
反应条件
hydrogen bromide; copper(I) bromide; sodium nitrite 1.) RT, 1 h, 2.) water, 100 deg C, 1 h; Yield given. Multistep reaction;
参考文献
The Regents of the University of Michigan
Patent: US5248672 A1, 1993 ;
反应条件
1: 91 percent / H2O; methanol 2: CuBr2, tert-butyl nitrite / acetone / 2 h View Scheme
参考文献
Townsend, Leroy B.; Devivar, Rodrigo V.; Turk, Steven R.; Nassiri, M. Reza; Drach, John C.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 20 p. 4098 - 4105
反应条件
1: 98 percent / H2, Raney nickel / ethanol / 2068.6 Torr 2: 91 percent / H2O; methanol 3: CuBr2, tert-butyl nitrite / acetone / 2 h View Scheme
参考文献
Porcari, Anthony R.; Devivar, Rodrigo V.; Kucera, Louis S.; Drach, John C.; Townsend, Leroy B.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 8 p. 1252 - 1262
