2-氯-4,6-二甲基-3-氰基吡啶合成路线 （共 33 条）
反应条件
sodium sulfide 1) water, 6 h, reflux, 2) 2 h, reflux; Yield given. Multistep reaction;
参考文献
Abbady, M. S.
Phosphorus, Sulfur and Silicon and the Related Elements, 1992 , vol. 68, # 1-4 p. 69 - 76
反应条件
sodium carbonate in ethanol
4 h; Reflux;
参考文献
Waly, Mohamed A.; El-Hawary, Ibrahim I.; Hamama, Wafaa S.; Zoorob, Hanafi H.
Journal of Heterocyclic Chemistry, 2013 , vol. 50, # SUPPL.1 p. E12-E17
反应条件
1: hydrogenchloride; zinc / water
2: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 1 h
View Scheme
参考文献
Rudenko; Kucherak; Tolmachev; Hordiyenko
Chemistry of Heterocyclic Compounds, 2011 , vol. 47, # 8 p. 964 - 969
反应条件
hydroxylamine hydrochloride; triethylamine in toluene
6 h; Reflux;
参考文献
Yassin
Chemistry of Heterocyclic Compounds, 2009 , vol. 45, # 1 p. 35 - 41
参考文献
Shevdov,V.I. et al.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1979 , vol. 15, p. 1070 - 1074
Khimiya Geterotsiklicheskikh Soedinenii, 1979 , vol. 15, p. 1331 - 1335
反应条件
1: 1.) selenourea, 2.) KOH / 1.) C2H5OH, reflux, 6 h; 2.) C2H5OH, reflux, 1 h
2: 80 percent / 10percent aq. KOH / dimethylformamide / 0.25 h
View Scheme
参考文献
Litvinov, V. P.; Mortikov, V. Yu.; Sharanin, Yu. A.; Shestopalov, A. M.
Synthesis, 1985 , # 1 p. 98 - 99
反应条件
hydrogenchloride; palladium on activated charcoal
P=1029.7 Torr; Hydrogenation;
参考文献
Coats, Steven J.; Dyatkin, Alexey B.; He, Wei; Lisko, Joseph; Miskowski, Tamara; Ralbovsky, Janet L.; Schulz, Mark
Patent: US2008/269225 A1, 2008 ;
Location in patent: Page/Page column 29 ;
US 20080269225 A1
参考文献
Japan Tobacco Inc.
Patent: US2007/32529 A1, 2007 ;
US 20070032529 A1
参考文献
Japan Tobacco Inc.
Patent: US2007/32529 A1, 2007 ;
US 20070032529 A1
反应条件
2: lithium aluminium tetrahydride / tetrahydrofuran
View Scheme
参考文献
PFIZER INC.; EDWARDS, Martin Paul; KUMPF, Robert Arnold; KUNG, Pei-Pei; MCAPLINE, Indrawan James; NINKOVIC, Sacha; RUI, Eugene Yuanjin; SUTTON, Scott Channing; TATLOCK, John Howard; WYTHES, Martin James; Zehnder, Luke Raymond
Patent: US2014/179667 A1, 2014 ;
