2-乙酰氨基-5-溴-4-甲基吡啶合成路线 (共 10 条)
反应条件
N-bromosuccinmide in N,N-dimethyl-formamide T=0°C; 0.5 h;
参考文献
ISHIHARA SANGYO KAISHA, LTD.
Patent: WO2009/88103 A1, 2009 ;
Location in patent: Page/Page column 15 ;
反应条件
bromine in dichloromethane
参考文献
Dunn; Norrie
Advanced Synthesis and Catalysis, 1996 , vol. 338, # 7 p. 663 - 666
参考文献
WO2012/106189 A1, ;
Page/Page column 13 ;
反应条件
1: nitric acid; sulfuric acid 2: chloro-trimethyl-silane; sodium nitrite 4: sodium methylate; ammonium chloride / copper(l) iodide / tetrahydrofuran 5: hydrogen / 1 wt Pd/C / ethyl acetate View Scheme
反应条件
1: nitric acid; sulfuric acid 2: chloro-trimethyl-silane; sodium nitrite View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; TRIPP, Jonathan Clive; FANFAIR, Dayne Dustan; SCHULTZ, Mitchell J.; MURUGESAN, Saravanababu; FOX, Richard J.; CHEN, Chung-Pin H.; IVY, Sabrina E.; PAYACK, Joseph Francis; DOUBLEDAY, Wendel W.
Patent: WO2012/106189 A1, 2012 ;
参考文献
ICHIKAWA GOSEI CHEMICAL CO., LTD.
Patent: EP530524 A1, 1993 ;
反应条件
sulfuric acid; nitric acid
参考文献
BRISTOL-MYERS SQUIBB COMPANY; TRIPP, Jonathan Clive; FANFAIR, Dayne Dustan; SCHULTZ, Mitchell J.; MURUGESAN, Saravanababu; FOX, Richard J.; CHEN, Chung-Pin H.; IVY, Sabrina E.; PAYACK, Joseph Francis; DOUBLEDAY, Wendel W.
Patent: WO2012/106189 A1, 2012 ;
Location in patent: Page/Page column 13-14 ;
反应条件
1: nitric acid; sulfuric acid
2: chloro-trimethyl-silane; sodium nitrite
4: sodium methylate; ammonium chloride / copper(l) iodide / tetrahydrofuran
5: hydrogen / 1 wt Pd/C / ethyl acetate
6: trichlorophosphate
7: 4-Me-2-pentanol
View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; TRIPP, Jonathan Clive; FANFAIR, Dayne Dustan; SCHULTZ, Mitchell J.; MURUGESAN, Saravanababu; FOX, Richard J.; CHEN, Chung-Pin H.; IVY, Sabrina E.; PAYACK, Joseph Francis; DOUBLEDAY, Wendel W.
Patent: WO2012/106189 A1, 2012 ;
反应条件
1: nitric acid; sulfuric acid
2: chloro-trimethyl-silane; sodium nitrite
4: sodium methylate; ammonium chloride / copper(l) iodide / tetrahydrofuran
View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; TRIPP, Jonathan Clive; FANFAIR, Dayne Dustan; SCHULTZ, Mitchell J.; MURUGESAN, Saravanababu; FOX, Richard J.; CHEN, Chung-Pin H.; IVY, Sabrina E.; PAYACK, Joseph Francis; DOUBLEDAY, Wendel W.
Patent: WO2012/106189 A1, 2012 ;