3,5-二甲基-4-硝基吡啶-N-氧化物合成路线 （共 10 条）
反应条件
sulfuric acid; nitric acid T=20 - 90°C; 6 h;
参考文献
Fortage, Jerome; Peltier, Cyril; Perruchot, Christian; Takemoto, Yohei; Teki, Yoshio; Bedioui, Fethi; Marvaud, Valerie; Dupeyre, Gregory; Pospisil, Lubomir; Adamo, Carlo; Hromadova, Magdalena; Ciofini, Ilaria; Laine, Philippe P.
Journal of the American Chemical Society, 2012 , vol. 134, # 5 p. 2691 - 2705
反应条件
sulfuric acid; nitric acid T=85 - 90°C; 6 h;
参考文献
Diemer, Vincent; Chaumeil, Helene; Defoin, Albert; Fort, Alain; Boeglin, Alex; Carre, Christiane
European Journal of Organic Chemistry, 2008 , # 10 p. 1767 - 1776
反应条件
titanium in tetrahydrofuran 0.25 h; Ambient temperature; Yield given;
参考文献
Fortage, Jerome; Peltier, Cyril; Perruchot, Christian; Takemoto, Yohei; Teki, Yoshio; Bedioui, Fethi; Marvaud, Valerie; Dupeyre, Gregory; Pospisil, Lubomir; Adamo, Carlo; Hromadova, Magdalena; Ciofini, Ilaria; Laine, Philippe P.
Journal of the American Chemical Society, 2012 , vol. 134, # 5 p. 2691 - 2705
反应条件
1: PCl3 / CHCl3 / 1.5 h / 69.9 - 79.9 °C 2: 79.2 percent / LiAlH4 / diethyl ether / 2.5 h / Heating View Scheme
参考文献
Polish Journal of Chemistry, , vol. 58, # 7-8-9 p. 871 - 876
反应条件
1: 90 percent / tert-BuOK / 50 - 60 °C 2: 0.5 h / 110 - 120 °C 3: ammonium persulfate / methanol; H2O / Heating 4: 1) SOCl2, 2) MeONa / 1) CHCl3, reflux, 2) MeOH, reflux View Scheme
参考文献
Kubo; Oda; Kaneko; Satoh; Nohara
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 10 p. 2853 - 2858
反应条件
1: 90 percent / tert-BuOK / 50 - 60 °C 2: 0.5 h / 110 - 120 °C 3: ammonium persulfate / methanol; H2O / Heating 4: 1) SOCl2, 2) MeONa / 1) CHCl3, reflux, 2) MeOH, reflux 5: 76 percent / m-chloroperbenzoic acid / CHCl3 / ice-cooling View Scheme
参考文献
Kubo; Oda; Kaneko; Satoh; Nohara
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 10 p. 2853 - 2858
参考文献
Rhone-Poulenc Rorer Limited
Patent: US6303600 B1, 2001 ;
US 6303600 B1
反应条件
acetyl-bromide in chloroform
1 h; Heating;
参考文献
Laihia; Puszko; Linnanto; Kolehmainen
Journal of Molecular Structure, 2006 , vol. 783, # 1-3 p. 73 - 78
反应条件
1: With palladium 10 on activated carbon in ethanol
T=90°C; 1 h; Inert atmosphere;
2: With hydrazine hydrate in ethanol
T=90°C; 3 h; Inert atmosphere;
参考文献
Fortage, Jerome; Peltier, Cyril; Perruchot, Christian; Takemoto, Yohei; Teki, Yoshio; Bedioui, Fethi; Marvaud, Valerie; Dupeyre, Gregory; Pospisil, Lubomir; Adamo, Carlo; Hromadova, Magdalena; Ciofini, Ilaria; Laine, Philippe P.
Journal of the American Chemical Society, 2012 , vol. 134, # 5 p. 2691 - 2705
反应条件
1: With phosphorus trichoride in dichloromethane
T=0 - 20°C; 0.5 h;
2: With sodium hydroxide; water in dichloromethane
0.166667 h;
参考文献
BAYER PHARMACEUTICALS CORPORATION
Patent: WO2007/27842 A1, 2007 ;
Location in patent: Page/Page column 91-92 ;
