反应条件
1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl acetamide / 12 h / 0 °C / |Inert atmosphere
2: sodium hydroxide / methanol / 20 - 50 °C
View Scheme
参考文献
MERCK SHARP and DOHME CORP.; MERCK SHARP and DOHME LIMITED; BEUTNER, Gregory, L.; WENSLOW, Robert, M., Jr.; CHOI, Eric, J.; SHULTZ, Clinton Scott; SCOTT, Jeremy; ARREDONDO, Juan, D.; ARTINO, Laura
Patent: WO2013/28465 A1, 2013 ;