1.1: lithium aluminium tetrahydride / diethyl ether / 3 h / 20 °C / |Cooling with ice 1.2: 0.5 h / |Cooling with ice 2.1: pyridine; trimethylsilyl iodide / sulfolane / 20 h / 70 °C / |Inert atmosphere 3.1: sodium hydroxide; oxygen / water; acetone / 18 h / 20 °C 4.1: hydrogenchloride / tetrahydrofuran / 20 h / 60 °C View Scheme

<b>Multi-step reaction with 3 steps<br /> </b>1: potassium carbonate / tetrahydrofuran / 12 h / 20 &deg;C<br />2: sodium hydride / tetrahydrofuran; mineral oil / 20.5 h / 50 &deg;C / |Cooling with ice; |Inert atmosphere<br />3: palladium diacetate; silver(l) oxide; potassium acetate / N,N-dimethyl-formamide / 110 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 5 steps<br /> </b>1: dihydrogen peroxide; potassium dihydrogenphosphate; sodium chlorite / tetrahydrofuran; water / 8 h / 20 &deg;C<br />2: thionyl chloride / chloroform / 6 h / |Reflux<br />3: potassium carbonate / tetrahydrofuran / 12 h / 20 &deg;C<br />4: sodium hydride / tetrahydrofuran; mineral oil / 20.5 h / 50 &deg;C / |Cooling with ice; |Inert atmosphere<br />5: palladium diacetate; silver(l) oxide; potassium acetate / N,N-dimethyl-formamide / 110 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 6 steps<br /> </b>1: trichlorophosphate / 1,2-dichloro-benzene / 3 h / 70 &deg;C / |Cooling with ice<br />2: dihydrogen peroxide; potassium dihydrogenphosphate; sodium chlorite / tetrahydrofuran; water / 8 h / 20 &deg;C<br />3: thionyl chloride / chloroform / 6 h / |Reflux<br />4: potassium carbonate / tetrahydrofuran / 12 h / 20 &deg;C<br />5: sodium hydride / tetrahydrofuran; mineral oil / 20.5 h / 50 &deg;C / |Cooling with ice; |Inert atmosphere<br />6: palladium diacetate; silver(l) oxide; potassium acetate / N,N-dimethyl-formamide / 110 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: sodium hydride / tetrahydrofuran; mineral oil / 20.5 h / 50 &deg;C / |Cooling with ice; |Inert atmosphere<br />2: palladium diacetate; silver(l) oxide; potassium acetate / N,N-dimethyl-formamide / 110 &deg;C<br /> <br /> &nbsp;