2-(n-甲氧基-n-甲基氨基甲酰)乙基氨基甲酸叔丁酯合成路线 （共 10 条）
反应条件
1: N-tert-butoxycarbonyl-β-alanine With 4-methyl-morpholine; isobutyl chloroformate in dichloromethane T=-15°C; 0.25 h; 2: O,N-dimethyl-hydroxylamine hydrochloride in dichloromethane T=-15 - 20°C; 16 h;
参考文献
Blaney, Paul; Grigg, Ronald; Rankovic, Zoran; Thornton-Pett, Mark; Xu, Juan
Tetrahedron, 2002 , vol. 58, # 9 p. 1719 - 1737
反应条件
1: N-tert-butoxycarbonyl-β-alanine With 1,1'-carbonyldiimidazole in tetrahydrofuran T=20°C; 4 h; 2: N-methoxymethyl amine hydrochloride With triethylamine in tetrahydrofuran 2 h; Further stages.;
参考文献
Incarvito; Lam; Rhatigan; Rheingold; Jin Qin; Gavrilova; Bosnich
Journal of the Chemical Society, Dalton Transactions, 2001 , # 23 p. 3478 - 3488
反应条件
1: triethylamine; isobutyl chloroformate / tetrahydrofuran 2: silver nitrate; triethylamine / tetrahydrofuran View Scheme
参考文献
Gouault, Nicolas; Le Roch, Myriam; Cheignon, Adele; Uriac, Philippe; David, Michele
Organic Letters, 2011 , vol. 13, # 16 p. 4371 - 4373
反应条件
silver nitrate; triethylamine in tetrahydrofuran
参考文献
Gouault, Nicolas; Le Roch, Myriam; Cheignon, Adele; Uriac, Philippe; David, Michele
Organic Letters, 2011 , vol. 13, # 16 p. 4371 - 4373
反应条件
1: N-methylmorpholine / CH2Cl2 / 0.25 h / -15 °C 2: 25.5 g / CH2Cl2 / 36.25 h / -15 - 20 °C View Scheme
参考文献
Shen, Jun-Wei; Qin, Dong-Guang; Zhang, Hong-Wang; Yao, Zhu-Jun
Journal of Organic Chemistry, 2003 , vol. 68, # 19 p. 7479 - 7484
反应条件
1: 98 percent / K2CO3 / H2O; dioxane 2: N-methylmorpholine / CH2Cl2 / 0.25 h / -15 °C 3: 25.5 g / CH2Cl2 / 36.25 h / -15 - 20 °C View Scheme
参考文献
Shen, Jun-Wei; Qin, Dong-Guang; Zhang, Hong-Wang; Yao, Zhu-Jun
Journal of Organic Chemistry, 2003 , vol. 68, # 19 p. 7479 - 7484
反应条件
in dichloromethane T=-15 - 20°C; 36.25 h;
参考文献
Shen, Jun-Wei; Qin, Dong-Guang; Zhang, Hong-Wang; Yao, Zhu-Jun
Journal of Organic Chemistry, 2003 , vol. 68, # 19 p. 7479 - 7484
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran; diethyl ether T=-10°C; 0.166667 - 0.333333 h; 2: With potassium hydrogensulfate in tetrahydrofuran; diethyl ether; water 0.25 h;
参考文献
Myriad Pharmaceuticals, Inc.
Patent: US2004/14763 A1, 2004 ;
Location in patent: Page 20 ;
反应条件
in tetrahydrofuran T=0 - 20°C; Grignard reaction;
参考文献
Rossi, Matteo; Bang, Jeong-kyu; Mazur, Sharlyn; Iera, Jaclyn A.; Phillips, Darren C.; Zambetti, Gerard P.; Appella, Daniel H.
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 9 p. 2429 - 2434
反应条件
1: 61 percent / LiAlH4 / diethyl ether / 1 h / Ambient temperature 2: 57 percent / NaBH3CN / methanol / 18 h / Ambient temperature 3: 78 percent View Scheme
参考文献
Bitan, Gal; Muller, Dan; Kasher, Ron; Gluhov, Evgenia V.; Gilon, Chaim
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 10 p. 1501 - 1510
