1.1: sodium hydride / ethylene glycol dimethyl ether; mineral oil / 3.75 h / -40 - 20 °C / |Inert atmosphere; |Reflux 2.1: acetic acid / tetrahydrofuran; water / 20 °C 3.1: hydrogen; potassium hydroxide; 5 palladium on charcoal / methanol / 20 °C 4.1: potassium carbonate; tetrabutylammomium bromide / acetone / 30 °C 5.1: water; potassium hydroxide / methanol / 3 h / |Reflux 5.2: pH 2 View Scheme