反应条件
1: n-butyllithium / tetrahydrofuran / 0.17 h / -78 - -65 °C 2: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / water; tetrahydrofuran / 15 h / |Inert atmosphere; |Reflux 3: tetrabutyl ammonium fluoride / tetrahydrofuran View Scheme
参考文献
CRYSTAL PHARMA, S.A.U.; Perez Encabo, Alfonso; Turiel Hernandez, Jose Angel; Gallo Nieto, Francisco Javier; Lorente Bonde-Larsen, Antonio; Sandoval Rodriguez, Celso Miguel
Patent: US2014/11992 A1, 2014 ;
