3-(Boc-氨甲基)哌啶合成路线 （共 5 条）
反应条件
hydrogen; ruthenium in methanol T=60°C; P=75006 Torr;
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 23 p. 3889 - 3901
反应条件
1: 100 percent / dioxane / 3 h / Ambient temperature 2: 89 percent / H2 / ruthenium on alumina / methanol / 60 °C / 75006 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 23 p. 3889 - 3901
反应条件
1: 100 percent / dioxane / 3 h / Ambient temperature 2: 89 percent / H2 / ruthenium on alumina / methanol / 60 °C / 75006 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 23 p. 3889 - 3901
反应条件
hydrogen; palladium(II) hydroxide/carbon in ethanol; ethyl acetate P=750.075 Torr;
参考文献
WO2004/35569 A2, ;
Page/Page column 21-22 ;
反应条件
1.1: sodium tris(acetoxy)borohydride / tetrahydrofuran / 16 h
1.2: pH ~ 14
2.1: trifluoroacetic acid / dichloromethane / 18 h / 0 °C
2.2: pH ~ 14
View Scheme
参考文献
PROSIDION LIMITED; BLOXHAM, Jason; BRADLEY, Stuart Edward; SAMBROOK-SMITH, Colin Peter; SMYTH, Donald; KEILY, John; DAWSON, Graham John; RASAMISON, Chrystelle Marie; BELL, James Charles
Patent: WO2011/117254 A1, 2011 ;
WO 2011/117254 A1
