甲基3,5-二碘苯甲酸酯合成路线 （共 11 条）
反应条件
1.1: DIBAH / toluene / 1.67 h / -40 °C
2.1: 14.68 g / imidazole / dimethylformamide / 20 °C
3.1: n-BuLi / tetrahydrofuran; hexane / 0.75 h / -100 °C
3.2: 80 percent / tetrahydrofuran; hexane / 0.75 h / -100 °C
4.1: hydroxylamine hydrochloride / pyridine; ethanol / 60 °C
5.1: 11.85 g / NEt3; DMAP / CH2Cl2 / 0 - 20 °C
6.1: 97 percent / ammonia / diethyl ether / 48 h / 20 °C
7.1: Ag2O / diethyl ether / 1 h / 20 °C
8.1: 5.00 g / TBAF / tetrahydrofuran / 5 h / 0 - 20 °C
View Scheme
参考文献
Gallant, Michel; Sawyer, Nicole; Metters, Kathleen M.; Zamboni, Robert J.
Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 1 p. 63 - 72
